Background: Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes (T2D); however, the underlying mechanisms remain unknown. DNA methylation may play a role in this process.
Aim: To identify the genes associated with pesticide exposure and T2D by reviewing the current literature.
N6-methyladenosine (m6A) modification is a common epigenetic modification. It is reported that lncRNA can be regulated by m6A modification. Previous studies have shown that lncRNAs associated with m6A regulation (m6A-lncRNAs) serve as ideal prognostic biomarkers.
View Article and Find Full Text PDFTo analyze the spatial-temporal distribution and sedimentation characteristics of suspended solids in reservoirs, high-frequency monitoring of a sediment trap and buoy, combined with three-dimensional water sampling, was conducted and analyzed in Xin'anjiang Reservoir for a year. The results showed that the turbidity data of the buoy has significant correlation with rainfall, inflow, and suspended solids (SS), particularly for SS (<0.01, =0.
View Article and Find Full Text PDFSchisantherin A is an active ingredient originating from (Turcz.) which has hepatoprotective and anti-oxidation activities. In this study, in vitro metabolisms investigated on rat liver microsomes (RLMs) and in vivo metabolisms explored on male Sprague Dawley rats of Schisantherin A were tested, respectively.
View Article and Find Full Text PDF: Hypoxia has been proved to contribute to aggressive phenotype of cancers, while functional and regulatory mechanism of long noncoding RNA (lncRNA) in the contribution of hypoxia on pancreatic cancer (PC) tumorigenesis is incompletely understood. The aim of this study was to uncover the regulatory and functional roles for hypoxia-induced lncRNA-MTA2TR (MTA2 transcriptional regulator RNA, AF083120.1) in the regulation of PC tumorigenesis.
View Article and Find Full Text PDFEach year influenza virus infections cause hundreds of thousands of deaths worldwide and a significant level of morbidity with major economic burden. At the present time, vaccination with inactivated virus vaccine produced from embryonated chicken eggs is the most prevalent method to prevent the infections. However, current influenza vaccines are only effective against closely matched circulating strains and must be updated and administered yearly.
View Article and Find Full Text PDFCancer cells are known to undergo metabolic reprogramming, such as glycolysis and glutamine addiction, to sustain rapid proliferation and metastasis. It remains undefined whether long noncoding RNAs (lncRNA) coordinate the metabolic switch in pancreatic cancer. Here we identify a nuclear-enriched antisense lncRNA of glutaminase (GLS-AS) as a critical regulator involved in pancreatic cancer metabolism.
View Article and Find Full Text PDFA new class of 1-[(1R,2S)-2-fluorocyclopropyl]ciprofloxacin (CPFX)-1,2,4-triazole-5(4H)-thione hybrids 6a - 6o was designed, synthesized and evaluated for their in vitro antibacterial activities against a panel of clinically important drug-sensitive and drug-resistant Gram-positive and Gram-negative pathogens. Our results revealed that all hybrids 6a - 6o had great potency against the tested strains, especially Gram-negative pathogens. The synthesized hybrids were more potent than the parent 1-[(1R,2S)-2-fluorocyclopropyl]CPFX (1) and comparable to CPFX and levofloxacin against the majority of the tested pathogens, worth to be further investigated.
View Article and Find Full Text PDFThe contribution of long noncoding RNAs (lncRNAs) to pancreatic cancer progression and the regulatory mechanisms of their expression are attractive areas. In the present study, the overexpression of lncRNA-BX111887 (BX111) in pancreatic cancer tissues was detected by microarray and further validated in a cohort of pancreatic cancer tissues. We further demonstrated that knockdown or overexpression of BX111 dramatically repressed or enhanced proliferation and invasion of pancreatic cancer cells.
View Article and Find Full Text PDFBis-coumarins have caused great interests in the recent years. These compounds exhibit diverse biological activities which are ascribed to their ability to exert noncovalent interactions with the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved for therapeutic purposes in clinical practice.
View Article and Find Full Text PDFBacterial infections represent a significant health threat globally, and are responsible for the majority of hospital-acquired infections, leading to extensive mortality and burden on global healthcare systems. The second generation fluoroquinolone ciprofloxacin which exhibits excellent antimicrobial activity and pharmacokinetic properties as well as few side effects is introduced into clinical practice for the treatment of various bacterial infections for around 3 decades. The emergency and widely spread of drug-resistant pathogens making ciprofloxacin more and more ineffective, so it's imperative to develop novel antibacterials.
View Article and Find Full Text PDFMalaria still remains one of the leading deadliest diseases throughout the world, leading to around 1 million deaths annually. The emergence and spread of growing resistance to the firstline antimalarials are an alarming the serious problem in malaria control, demanding the need for new drugs more potent than earlier with improved Absorption, Distribution, Metabolism, and Excretion (ADME) profiles. Coumarins, which exhibited various biological properties, also displayed potential in vitro antiplasmodial and in vivo antimalarial activities.
View Article and Find Full Text PDFFungi place a huge burden on global healthcare systems attributed to the fact that fungal infections are responsible for the high morbidity and mortality rates in patients who received stem cell transplantation, antineoplastic chemotherapy, organ transplants or suffered Human Immunodeficiency Virus (HIV) infection. Unfortunately, almost none of the representative anti-fungal agents currently used in clinical therapy are ideal in terms of efficacy, anti-fungal spectrum or safety. Moreover, the rapid development of resistance to existing anti-fungal drugs has further aggravated the mortality and spread of fungi, creating an urgent need for novel anti-fungal agents.
View Article and Find Full Text PDFThe emergence and wide-spread of drug-resistant bacteria including multi-drug resistant and pan-drug resistant pathogens which are associated with considerable mortality, represent a significant global health threat. 4-Quinolones which are exemplified by fluoroquinolones are the second largest chemotherapy agents used in clinical practice for the treatment of various bacterial infections. However, the resistance of bacteria to 4-quinolones develops rapidly and spreads widely throughout the world due to the long-term, inappropriate use and even abuse.
View Article and Find Full Text PDFA series of novel 8-OMe ciprofloxacin (CPFX)-hydrazone/azole hybrids were designed, synthesized, and evaluated for their in vitro biological activities. Our results reveal that all of the hydrozone-containing hybrids (except for ) show potency against (MTB) HRv (minimum inhibitory concentration (MIC): <0.5 μM), which is better than the parent drug CPFX, and comparable to moxifloxacin and isoniazid, some of the tested Gram-positive strains (MIC: 0.
View Article and Find Full Text PDFA series of 12-oxime and O-oxime ether derivatives of dehydroabietic acid were synthesized and investigated for the antibacterial activity against Staphylococcus aureus Newman strain and five multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). The aromatic oximate derivative 11a showed the highest activity with MIC of 0.39-0.
View Article and Find Full Text PDFPhotosynthetically active radiation (PAR) is defined as the wavelength band of 400 to 700 nm, representing most of the visible solar radiation that could be used for photosynthesis. PAR is attenuated by the absorption and scattering of nonpigment suspended matter, chromophoric dissolved organic matter and phytoplankton, and it plays an important role in determining the density and distribution of aquatic organisms. This study developed an empirical model and presented the spatial-temporal distribution of PAR diffuse attenuation coefficient [Kd (PAR)] for the slightly turbid Xin'anjiang Reservoir based on the in situ ground data and the matching Landsat 8 data.
View Article and Find Full Text PDFBased on monthly in situ data collected at six sampling sites in Qiandaohu Lake between 2011 and 2012, the dynamic distributions of dissolved oxygen (DO) were analyzed and the relationships between DO and the environmental factors were investigated. The results showed that there were obviously vertical and temporal variations in the distributions of DO. In winter, the average values of DO were generally higher than those in other seasons, but no significant vertical distribution variation was found except Dabaqian.
View Article and Find Full Text PDFActa Crystallogr C Struct Chem
February 2014
The title organic-inorganic hybrid salts poly[trimethylsulfonium [[dichloridoantimony(III)]-di-μ-chlorido]], {(C3H9S)[SbCl4]}n, (I), and catena-poly[trimethylsulfonium [cadmium(II)-tri-μ-chlorido]], {(C3H9S)[CdCl3]}n, (II), consist of trimethylsulfonium cations and polymeric {[SbCl4](-)}n or {[CdCl3](-)}n anions. The central metal atoms are coordinated by six Cl atoms, forming an anionic {[SbCl4](-)}n three-dimensional framework (two of the four bridging chloride anions are located on two different centres of inversion) or anionic {[CdCl3](-)}n one-dimensional chains. The trimethylsulfonium cation of (II) is disordered over two sets of sites in a 0.
View Article and Find Full Text PDFThe title salt, catena-poly[trimethylsulfonium [μ2-chlorido-di-μ2-thiocyanato-cadmate(II)]] {(C3H9S)[CdCl(NCS)2]}n, consists of trimethylsulfonium cations sandwiched between layers of a two-dimensional polyanion. The Cd(II) centre displays a distorted octahedral environment coordinated by two bridging Cl atoms, two thiocyanate N atoms and two thiocyanate S atoms. The thiocyanate groups adopt the μ-1,3-coordination mode and bridge the Cd(II) centres into a one-dimensional zigzag chain extended along the [110] direction.
View Article and Find Full Text PDFThe title compound, (C₂₄H₂₄N₇)₂[Cd₅Cl₁₆(H₂O)₄]·H₂O, contains a [Cd₅Cl₁₆(H₂O)₄]⁶⁻ anion, two triply protonated tris[(1H-benzimidazol-3-ium-2-yl)methyl]amine cations and one solvent water molecule. The structure of the anion is a novel chloride-bridged pentanuclear cluster. The five unique CdII centres have quite different coordination environments.
View Article and Find Full Text PDFActa Crystallogr C
January 2013
The hydrothermal reaction of 2-(quinolin-8-yloxy)acetonitrile and Cd(ClO(4))(2) yielded the noncentrosymmetric coordination complex tetrakis[μ-2-(quinolin-8-yloxy)acetato]tetrakis[μ-2-(quinolin-8-yloxy)acetonitrile]tetracadmium tetrakis(perchlorate) dihydrate, [Cd(4)(C(11)H(8)NO(3))(4)(C(11)H(8)N(2)O)(4)](ClO(4))(4)·2H(2)O. The local coordination environment around the Cd(II) cation can be best described as a capped octahedron defined by two N atoms and five O atoms from three ligands. The Cd(II) cations are linked by the ligands with Cd-O-Cd and Cd-O-C-C-O-Cd bridges, forming tetranuclear units, there being two independent tertranuclear units in the structure.
View Article and Find Full Text PDFWe report herein the design and synthesis of a series of novel ciprofloxacin (CPFX) derivatives with remarkable improvement in lipophilicity by introducing a substituted benzyl moiety to the N atom on the C-7 piperazine ring of CPFX. Antimycobacterial and antibacterial activity of the newly synthesized compounds was evaluated. Results reveal that compound 4f has good in vitro activity against all of the tested Gram-positive strains including MRSA and MRSE (MICs: 0.
View Article and Find Full Text PDFActa Crystallogr Sect E Struct Rep Online
June 2012
In the crystal of the title mol-ecular salt, 2C(7)H(10)N(+)·C(10)H(6)O(6)S(2) (2-), the naphthalene-1,5-disulfonate anion is located on an inversion center and accepts N-H⋯O hydrogen bonds from the 3-methyl-anilinium cations, forming supra-molecular layers parallel to the ac plane.
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