Identification and Functional Analysis of PANoptosis-Associated Genes in the Progression From Sepsis to ARDS.

Background: Sepsis and acute respiratory distress syndrome (ARDS) are common inflammatory conditions in intensive care, with ARDS significantly increasing mortality in septic patients. PANoptosis, a newly discovered form of programmed cell death involving multiple cell death pathways, plays a critical role in inflammatory diseases. This study aims to elucidate the PANoptosis-related genes (PRGs) and their involvement in the progression of sepsis to ARDS.

Overexpression of OsSTP1 increases grain yield via enhancing carbohydrate metabolism and transport in rice.

Overexpression of OsSTP1 enhances the non-structural carbohydrate remobilization in the source, starch accumulation in grains, and the transportation of carbohydrates from source to sink during the filling stage. The sugar transporter protein (STP) is the best-characterized subfamily of the monosaccharide transporter (MST) family and plays critical roles in regulating plant stress tolerance, growth, and development. However, the role of STPs in regulating rice yield is poorly understood.

Poly(I:C)-induced maternal immune activation causes elevated self-grooming in male rat offspring: Involvement of abnormal postpartum static nursing in dam.

Maternal immune activation (MIA) is closely related to the onset of autism-like behaviors in offspring, but the mechanism remains unclear. Maternal behaviors can influence offspring's development and behaviors, as indicated in both human and animal studies. We hypothesized that abnormal maternal behaviors in MIA dams might be other factors leading to delayed development and abnormal behaviors in offspring.

[Advance on pharmacokinetics study of traditional Chinese medicine injections in recent ten years].

Traditional Chinese medicine(TCM) injections boast a definite efficacy and have been widely used in clinic. However, the problems in medication safety have been attracted increasing attention. Pharmacokinetics is of significance to guiding TCM injection administration regimen design and improving safety and effectiveness in clinical use.

Association between serum bilirubin concentration and Parkinson's disease: a meta-analysis.

Background: The antioxidant effects of bilirubin in Parkinson's disease (PD) have recently gained much attention from the research community. However, results from these studies have been conflicting. This meta-analysis is conducted to assess the relationship between the serum bilirubin concentration and the risk of PD.

[Extraction of flavonoids in Prunella vulgaris based on deep eutectic solvent method：application of new green solvent].

Flavonoids have attracted much attention due to their good anti-inflammatory, anti-oxidation and anti-tumor effects. At present, the extraction of flavonoids is mainly based on organic solvent, while the researches on the use of green and safe solvents are quite limited. Therefore, in the present study, different types of deep eutectic solvents (DESs) were applied to investigate their effect on extraction of flavonoids and optimize the process, also investigate the recovery efficiency of DESs and evaluate the recovery method for total flavonoids.

Changes in the adhesion and migration ability of peripheral blood cells: potential biomarkers indicating exposure dose.

The expression of adhesion molecules and their related functions of adhesion and migration were investigated in peripheral blood mononuclear cells (PBMCs) to identify radiation-related changes and dose-dependency. The authors screened new biomarkers as radiation exposure dose indicators. Heparinized human peripheral blood was irradiated in vitro with different doses of γ-rays.

[Influence of superfine grinding technology on extracting flavones from plantain].

Objective: To study the influence of superfine grinding technology on extracting flavones from plantain and explore its optimum extraction technology.

Methods: Ultrasonic technology was used to extract the flavones in superfine grinding plantain, the content of flavone glycosides was determined by RP-HPLC.

Results: The optimum technology was as follows: the concentration of ethanol was 60%, temperature was 60 degrees C, solid-liquid ratio (g:mL) was 1:20 and extraction time was 20 min.

Excited state structures and decay dynamics of 1,3-dimethyluracils in solutions: resonance Raman and quantum mechanical calculation study.

The resonance Raman spectroscopic study of the excited state structural dynamics of 1,3-dimethyluracil (DMU), 5-bromo-1,3-dimethyluracil (5BrDMU), uracil, and thymine in water and acetonitrile were reported. Density functional theory calculations were carried out to help elucidate the ultraviolet electronic transitions associated with the A-, and B-band absorptions and the vibrational assignments of the resonance Raman spectra. The effect of the methylation at N1, N3 and C5 sites of pyrimidine ring on the structural dynamics of uracils in different solvents were explored on the basis of the resonance Raman intensity patterns.

Radiation dose effect of DNA repair-related gene expression in mouse white blood cells.

Background: The aim of this study was to screen molecular biomarkers for biodosimetry from DNA repair-related gene expression profiles.

Material/methods: Mice were subjected to whole-body exposure with 60Co gamma rays with a dose range of 0-8 Gy at a dose rate of 0.80 Gy/min.