Publications by authors named "Ming-juan Guo"

Limited treatment options and multidrug-resistant (MDR) present a significant therapeutic challenge, underscoring the need for novel approaches. Drug repurposing is a promising tool for augmenting the activity of many antibiotics. This study aimed to identify novel synergistic drug combinations against based on drug repurposing.

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Background emergence of multidrug-resistant (MDR) bacterial strains is a public health concern that threatens global and regional security. Efflux pump-overexpressing MDR strains from clinical isolates are the best subjects for studying the mechanisms of MDR caused by bacterial efflux pumps. A strain overexpressing the OqxB-only efflux pump was screened from a clinical strain library to explore reverse OqxB-mediated bacterial resistance strategies.

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Article Synopsis
  • - Homoisoflavonoids are a unique group of flavonoids, with over 110 compounds identified from natural sources.
  • - These compounds exhibit various bioactivities, including anti-inflammatory, estrogenic, antiestrogenic, anticancer, and angioprotective effects.
  • - The paper discusses the plant sources, structural characteristics, spectroscopic features, and biological activities of homoisoflavonoids.
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