Publications by authors named "Ming-jia Bao"
Article Synopsis
- - Clonorchiasis, caused by the liver fluke Clonorchis sinensis, poses risks for serious liver diseases, including cholangiocarcinoma, but its exact mechanisms and diagnostic markers are still not well understood.
- - A study involving 18 rabbits assessed the impact of C. sinensis infection on liver function and identified various biochemical changes and metabolites at multiple time points post-infection using advanced testing methods.
- - The findings revealed significant changes in liver function markers and identified several potential noninvasive biomarkers, like AST and GGT, useful for diagnosing C. sinensis infection effectively.
Article Synopsis
- The study focuses on identifying broadly cross-reactive neutralizing (BCN) antibodies, which are crucial for creating a universally effective HIV vaccine.
- A total of 117 serum samples from HIV-1 (CRF07_BC) individuals were tested, revealing that 18 samples could neutralize all three primary HIV-1 strains, with BCN sera showing a stronger neutralizing response compared to non-BCN sera.
- Additionally, sera from asymptomatic individuals were more effective at neutralizing key HIV strains than those from symptomatic individuals, suggesting that BCN responses could play a role in protecting against HIV infection and disease progression.
Article Synopsis
- TLR7 and TLR8 are crucial for recognizing viral RNA and could influence HIV infection and its progression.
- A study involving 81 individuals from China assessed how TLR7/8 expression and signaling in monocytes varied between HIV-infected and uninfected subjects.
- Results showed that TLR7/8 mRNA levels decreased with advancing disease, and stimulating these receptors with R-848 not only reduced HIV replication in cultured monocytes but also suggested potential for new treatments to delay HIV disease progression.
Background: Studies on human immunodeficiency virus type 1 (HIV-1) vaccines have recently focused on targeting the conserved neutralizing epitopes 2F5 and 4E10, and hence it is important to understand the extent of mutations in these two viral epitopes. Here, we investigated the amino acid mutations in epitopes of 2F5 (ELDKWA, HIV-1 HXB2 env 662 - 667 aa) and 4E10 (NWFDIT, HIV-1 HXB2 env 671 - 676 aa) in the membrane proximal-external region of gp41 from clade B' HIV-1-infected individuals living in Henan province, China. We also examined the frequency of a mutation and its relation to disease progression.
View Article and Find Full Text PDF