Publications by authors named "Ming-Zi Chen"
The aim of the present study was to investigate the effects of recombinant Escherichia coli (E. coli) Trx-jingzhaotoxin (JZTX)-III on cell growth in the mouse hepatocellular carcinoma (HCC) cell line Hepa1-6. The JZTX-III gene sequence was synthesized and cloned into the pET-32a(+) vector to construct the recombinant fusion protein Trx-JZTX-III, which was subsequently purified.
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- MicroRNAs, particularly miR-30b-5p, play a crucial role in regulating cardiac hypertrophy and the signaling marker CaMKIIδ, although the details of their integration into this process are still under investigation.
- This study identified miR-30b-5p as a significant regulator of CaMKIIδ, showing that its expression is notably reduced in hypertrophic models, indicating its potential suppressive role in cardiac hypertrophy.
- Experiments revealed that increasing miR-30b-5p levels can inhibit CaMKIIδ expression, suggesting that restoring miR-30b-5p function could be a therapeutic strategy in managing cardiac hypertrophy.
Cardiac hypertrophy is often associated with an increased sympathetic drive, and both in vitro and in vivo studies have demonstrated the development of cardiomyocyte hypertrophy in response to either α- or β- adrenergic stimulation. The present study was carried out to determine whether the reversible sodium channel blocker tetrodotoxin (TTX) exerts a direct anti-hypertrophic effect on isoproterenol (ISO)-induced cell hypertrophy and find the underlying mechanism that regulate [Na(+)]( i ). The experiments were performed on cultured H9c2 cells exposed to ISO (10 μM) alone or combined with TTX (1 μM) for 48 h.
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