Development and validation of a risk assessment model for predicting the failure of early medical abortions: A clinical prediction model study based on a systematic review and meta-analysis.

Objective: As the first model in predicting the failure of early medical abortion (EMA) was inefficient, this study aims to develop and validate a risk assessment model for predicting the failure of EMAs more accurately in a clinical setting.

Methods: The derivation cohort was obtained from a comprehensive systematic review and meta-analysis. The clinically significant risk factors were identified and combined with their corresponding odds ratios to establish a risk assessment model.

Mediating Effect of Cognitive Reserve in the Relationship Between Physical Activity and Cognitive Function in Community-Dwelling Older Adults.

The aim of this study was to investigate the mediating effect of cognitive reserve (CR) on the association between physical activity and cognitive function in community-dwelling older adults. A total of 495 community-dwelling older adults were included in this cross-sectional study. The CR, cognitive function, physical activity, and the potential confounders were assessed.

Structural characterisation of a novel polysaccharide from fibrous root and its anti-inflammatory and antioxidant activities .

A novel water-soluble polysaccharide, named PF90-1, with a molecular weight of 1.8 kDa, was isolated and purified from the fibrous root of . PF90-1 is composed of Gal, Glc and Man in a molar ratio of 73.

Chimeric CNS-targeting-peptide engineered exosomes for experimental autoimmune encephalomyelitis therapy.

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that causes demyelination, neuronal damage and white matter loss, but there is still no known cure. Exosomes are 30-200 nm-sized double-layered membrane vesicles that can easily cross the blood-brain barrier (BBB). Exosomes from umbilical cord mesenchymal stem cells（UMSCs） have been found to treat experimental autoimmune encephalomyelitis (EAE) through the action of anti-inflammatory and immunomodulatory, but its clinical translation has been hampered by their inefficacious accumulation in CNS.

Solid pseudopapillary neoplasm: Report of a case of primary ovarian origin and review of the literature.

Background: Solid pseudopapillary neoplasms (SPNs) are uncommon tumors of low malignancy with a generally favorable prognosis, mostly originating from the pancreas. To date, 12 cases of SPNs with a primary ovarian origin (SPN-Os) have been reported globally, and their detailed characteristics have not been fully elucidated.

Case Description: We reported the 13th SPN-O case, which occurred in a 52-year-old woman with an 18.

Optimal exercise parameters of tai chi for balance performance in older adults: A meta-analysis.

Background: Tai chi is considered a safe and low-cost treatment for improving balance ability among an older population. However, there is no existing evidence on the optimal exercise parameters of tai chi for improving balance in older adults.

Objectives: To investigate the optimal parameters of a tai chi intervention to improve balance performance of older adults.

[Thermal resources and maize temperature suitability in Northeast China under climate change].

This paper analyzed the spatiotemporal patterns of thermal resources and of temperature suitability of maize at its different growth stages in Northeast China, based on the 1951-2100 daily mean and minimum air temperature from RegCM3. In 1951-2100, the thermal resources in Northeast China had an obvious persistent increase, the first day of temperature > or = 10 degrees C continued to be advanced, and the north boundary line in the zone of the first date of temperature > or = 10 degrees C before April 25th moved eastward and northward. In 2071-2100, the first date in some areas of Liaoning Province would advance to March 26th, and the areas with active accumulated temperature > or = 10 degrees C more than 3000 degrees C x d, the length of growth season, and the areas suitable for late-maturing maize planting in Northeast China would increase persistently.

[Transfer and identification of multidrug resistance gene in mesenchymal stem cells derived from human placenta].

Objective: To explore the feasibility and safety of mdr1 gene transferred into placenta derived mesenchymal stem cells (P-MSCs) by reconstructed retroviral vector.

Methods: Human P-MSCs were isolated and expanded by Percoll density gradient and then transduced repeatedly by reconstructed retroviral vector containing mdr1 gene. The transfection and expression of mdr1 gene was detected by reverse transcription-polymerase chain reaction (RT-PCR) and fluorescence-activated cell sorting (FACS).

Transduction of mesenchymal stem cells with multidrug resistance gene provides protection for bone marrow toxicity after being transplanted into a nude mice model.

Background: Myelosuppression is the main dose-related toxicity of many chemotherapeutic drugs. The human multidrug resistance (mdr1) gene is well-known for its ability to confering drug resistance. In this study, we meant to transplant the placenta mesenchymal stem cells (P-MSCs) moderated by mdr1 gene into a nude mice model radiated by γ-Co(60) and to explore the chemoprotection for bone marrow (BM) toxicity.

[Retention of biological features in human placental mesenchymal stem cells transfected by multidrug resistance gene].

Objective: To transfer multidrug resistance gene (mdr1) into human placental mesenchymal stem cells (P-MSCs) by retroviral vector and assess the effects of mdr1 gene transduction upon biological features of P-MSCs.

Methods: Human P-MSCs were isolated from trypsin-digested term placentas and then transduced by reconstructed retroviral vector containing mdr1 gene and green fluorescent protein (GFP) reporter gene. Flow cytometric analysis was employed to determine the immunophenotypes of transfected P-MSCs.

Retroviral-mediated transfer and functional expression of multidrug resistance gene in human placenta mesenchymal stem cells.

Background: Most of gynecologic malignancies are sensitive to chemotherapy. Myelosuppression is the main dose-related toxicity of many chemotherapeutic drugs. The human multidrug resistance (mdr1) gene is well known for its ability to confer drug resistance.

[Cytotoxicity of dendritic cells pulsed by CpG ODN on ovarian carcinoma cells: in vitro experiment with ovarian carcinoma cells].

Objective: To investigate the effect of dendritic cells (DCs) pulsed by oligonucleotide containing "un-methylated cytimidine-phosphodiester bond-guanylic acid" motif (CpG ODN) on ovarian carcinoma cells.

Methods: Dendritic cells were isolated form the peripheral monocytes and co-incubated with synthesized CpG2006, CAI125, important epithelial ovarian cancer-associated antigen, or CpG ODN + CA125 for 72 h. Flow cytometry (FC) was used to detect the expression of CD(1alpha), CD(63), CD(86), and human leucocyte antigen-DR (HLA-DR) on the cell surface.

The role of the cuff leak test in predicting the effects of corticosteroid treatment on postextubation stridor.

Background: There is not enough evidence to determine the most appropriate treatment of postextubation stridor. Although the cuff leak test is a simple method to predict postextubation stridor, little is known about its use in monitoring the effects of steroid treatment for this complication. The aim of this study was to evaluate the effect of steroids on postextubation stridor based on the clinical response and the cuff leak test.