Publications by authors named "Ming-Zhan Zhang"
Article Synopsis
- The study investigates how variations in the BIN1 gene are linked to neuroinflammation and Alzheimer's disease (AD) pathology, focusing on two specific genetic polymorphisms: rs7561528 and rs744373.
- Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Chinese Alzheimer's Biomarker and Lifestyle (CABLE) study, researchers found a significant relationship between BIN1 loci and levels of key Alzheimer's biomarkers in cerebrospinal fluid (CSF), particularly phosphorylated-tau (P-tau), total-tau (T-tau), and microglial activation marker sTREM2.
- The findings suggest that the association between BIN1 loci and tau pathology is
Article Synopsis
- The study investigates the relationship between multimorbidity status (having multiple long-term conditions) and cerebrospinal fluid (CSF) biomarkers linked to neurodegenerative disorders in early-stage Parkinson's patients.
- A total of 827 participants were analyzed, including 638 with Parkinson's disease and 189 healthy controls, using regression models for both cross-sectional and longitudinal data.
- Results revealed that higher numbers of long-term conditions were associated with significant differences in various CSF biomarker levels, indicating that multimorbidity could increase neuronal damage in neurodegenerative diseases.
Background: The association between carotid plaque and cognitive decline has recently been reported. However, the current research evidence is insufficient, and the possible causes of cognitive changes are unknown.
Objective: This study aims to explore the relationships between carotid plaque and cognition functions, cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers in cognitively intact adults, and try to study the underlying mechanisms.