Profiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure.

Background: Hypoxia is a risk factor for non-alcoholic fatty liver diseases, leading to permanent imbalance of liver lipid homeostasis and steatohepatitis. However, a detailed understanding of the metabolic genes and pathways involved remains elusive.

Methods: In vivo experiments were designed to analyze body weight and lipid metabolism changes of rats under hypoxia.

DSEP: A Tool Implementing Novel Method to Predict Side Effects of Drugs.

Drug side effects, or adverse drug reactions, have become a focus of public health concern. Anticipating side effects before the drugs are granted marketing authorization for clinical use can help reduce health threats. An increasing need for methods and tools that facilitate side-effect prediction still remains.