Publications by authors named "Ming-Yang Guo"
Article Synopsis
- The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in over 6.4 million deaths globally, highlighting a significant link between hypertension and severe COVID-19 outcomes, potentially due to shared genetic factors.
- Researchers analyzed genetic data from over 1 million Europeans to identify a specific SNP, rs12474050, that shows a sex-biased association with severe COVID-19 in women, where the risk allele is linked to higher blood pressure.
- The study found that the gene related to rs12474050 shows different expression levels in various tissues, especially in females, suggesting that this gene may play a protective role against heart damage from COVID-19 in women.
Since the occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, SARS-CoV-2 has led to a global coronavirus disease 2019 (COVID-19) pandemic. A better understanding of the SARS-CoV-2 receptor at the genetic level would help combat COVID-19, particularly for long COVID. We performed a genetic analysis of and searched for its common potential single nucleotide polymorphisms (SNPs) with minor allele frequency >0.
View Article and Find Full Text PDFObjective: To investigate the negative feedback regulation from rat hippocampus on hypothalamic-pituitary-adrenal (HPA) axis under high temperature and high humidity stress.
Methods: Thirty (30) SD male rats were randomly divided into three groups: control group, high temperature and high humidity group, drug intervention group. The rats in control group were kept in the environment with temperature of 24 ± 1°C and humidity of 50 ± 5%, without any stimulation.
Objective: To investigate the effect and safety of the complementary use of the extract of Artemisia annua L. (EAA) on treating active rheumatoid arthritis (RA).
Methods: A randomized controlled clinical trial was performed.
Objective: To probe the function of interleukin-17 (IL-17) in rheumatoid arthritis (RA) patients of accumulated dampness-heat obstruction in joints syndrome (ADOJS) by detecting levels of IL-17 in serum and the synovial fluid and analyzing its correlation with erythrocyte sedimentation rate (ESR) and C reactive protein (CRP).
Methods: From January 2011 to January 2013, recruited were 90 RA inpatients of ADOJS at Department of Integrative Medical Rheumatism, General Hospital of Chengdu Military Region, of which 28 patients had knee joint effusion. Besides, 30 healthy volunteers who received physical examination at our hospital were recruited as the normal control group, and 30 patients with osteoarthritis (OA) who had knee joint effusion were recruited as the synovial fluid control group.
[Treatment of active rheumatoid arthritis by sanhuang yilong decoction].
Zhongguo Zhong Xi Yi Jie He Za Zhi
August 2008
Objective: To observe the clinical effect of Sanhuang Yilong Decoction (SYD) in treating active rheumatoid arthritis (RA).
Methods: Ninety patients of active RA were equally assigned to the treated group and the control group, they were treated by SYD and non-steroid anti-inflammatory drugs respectively. The effects on both clinical and laboratory indexes of patients were observed and compared.