Healthcare professionals' knowledge, attitude and practice towards ischemic bowel disease.

Background: Ischemic bowel disease (IBD) is a critical condition caused by reduced blood flow to the intestines, leading to tissue damage and potentially severe complications. Early recognition and timely management are essential for improving patient outcomes and reducing morbidity and mortality associated with IBD.

Aim: To evaluate the knowledge, attitude and practice (KAP) of healthcare professionals regarding IBD.

[NCTD Retards AML HL60 Cell Proliferation via Targeting Hedgehog/SOX2 axis].

Objective: To investigate the effect of norcantharidin (NCTD) to proliferation of leukemia cells through disrupting key regulators of sonic Hedgehog (SHH) pathway and its downstream transcription factor SOX2.

Methods: CCK8 was used to detected the HL60 and NB4 cells after inhibited by NCTD, SMO and GLI1 inhibitor for 24 hours. Expression level of SMO, GLI1 and SOX2 in HL60 cells with NCTD treatment was detected by immunoblot.