Publications by authors named "Ming-Xu Qiao"
DEK is a protein ubiquitously expressed in multicellular organisms as well as certain unicellular organisms. It is associated with the regulation of cell proliferation, differentiation, migration, apoptosis, senescence, self-renewal and DNA repairing. In tumor cells it is associated with the carcinogenesis process, however there have been few previous studies into the expression of DEK in lung cancer.
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- - DEK is found to be overexpressed in various invasive tumors, but the ways it is regulated at the genetic level remain unclear.
- - The study identifies the DEK core promoter region, showing that its methylation affects DEK expression, especially comparing levels in normal liver cells versus hepatocellular carcinoma (HCC) cells.
- - AP-2α is highlighted as a crucial transcription factor for DEK expression, with its binding influenced by methylation, and experiments show that altering AP-2α levels significantly affects DEK activity.