Publications by authors named "Ming-Wei Huang"

Objective: This trial was aimed at investigating the effects of progressive functional training on hip mobility, lower-limb stability, quality of life, and hip complications in patients who have undergone jaw defect reconstruction using vascularized iliac flaps.

Methods: Patients who underwent reconstruction surgery with vascularized iliac flaps were randomly divided into control and training groups. The control group, according to routine nursing practice, only received activity and safety guidance after the operation.

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Background: Risk factors associated with infection and traumatic lacerations affecting the face are still not fully understood. This study investigated risk factors for poor outcomes in adult patients with through-and-through lip wounds who underwent debridement and suturing.

Methods: Patients with through-and-through lip wounds who underwent debridement in our emergency department between January 1, 2017, and December 31, 2021, were included.

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Article Synopsis
  • The study aimed to assess how effective CAD/CAM technology is in designing and manufacturing 3D-printed dental models for creating splints for children with dental trauma.
  • Researchers treated 28 patients, splitting them into two groups: one received CAD/CAM-based splints and the other wire-composite splints, with follow-ups over 24 months.
  • Results indicated that while both splint types had similar outcomes, the CAD/CAM splint showed higher pulp survival and periodontal healing rates, suggesting its potential for reducing treatment-related injuries.
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  • Loss of chromosome 9p is a key indicator of the progression from oral leukoplakia to head and neck squamous cell carcinoma (HNSCC), which affects patient prognosis, but current methods to assess this loss are limited.
  • This study created a pathomics-based AI model called 9PLP, using data from 333 cases to effectively predict 9p loss in OLK and HNSCC images, achieving high accuracy in both prediction and patient prognosis.
  • The development of the 9PLP model represents a significant advancement in utilizing deep learning for genomic prediction, potentially improving clinical management and outcomes for HNSCC patients in the future.
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Objective: The superior thyroid artery perforator flap (STAPF) was previously presented as a type of locoregional pedicled flap for lateral facial and temple defects. In this study, we aimed to present our clinical experience with this flap for the reconstruction of soft tissue defects after oral cancer surgery.

Methods: From February 2019 to December 2022, 24 patients with oral cancers at the School and Hospital of Stomatology, Peking University were included.

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Objectives: We aim to develop a YOLOX-based convolutional neural network model for the precise detection of multiple oral lesions, including OLP, OLK, and OSCC, in patient photos.

Materials And Methods: We collected 1419 photos for model development and evaluation, conducting both a comparative analysis to gauge the model's capabilities and a multicenter evaluation to assess its diagnostic aid, where 24 participants from 14 centers across the nation were invited. We further integrated this model into a mobile application for rapid and accurate diagnostics.

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Background: Although the incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing since the past decade, the proportion of AEG cases in two previous clinical trials (ACTS-GC and CLASSIC) that investigated the efficacy of adjuvant chemotherapy was relatively small. Therefore, whether AEG patients can benefit from adjuvant chemotherapy remains unclear.

Methods: Patients who were diagnosed with pathological stage II/III, Siewert II/III AEG, and underwent curative surgery at three high-volume institutions were assessed.

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Gastric cancer (GC) is one of the most common gastrointestinal malignancies. Ferroptosis is a new type of peroxidation-driven and iron-dependent cell death. However, the biological functions and exact regulatory mechanisms of ferroptosis in GC remain elusive.

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Objectives: This study was performed to examine changes in the number of patient visits and types of oral services in an oral emergency department from the beginning to the control stage of the coronavirus disease 2019 (COVID-19) outbreak in Beijing.

Methods: The numbers of daily oral emergency visits from January 20 to March 24, 2020, at a dental university hospital in Beijing and daily newly confirmed COVID-19 cases in Beijing during the same period were collected and analysed. All oral emergency patient information (including sex, age, and oral diagnosis) was also collected and analysed.

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Purpose: The present study retrospectively evaluated the effectiveness and safety of iodine-125 interstitial brachytherapy for treatment of primary locally advanced adenoid cystic carcinoma (ACC) of the base of tongue (BOT).

Material And Methods: This study was a retrospective analysis of data of 19 patients with ACC, who were treated with iodine-125 interstitial brachytherapy between March 2008 and April 2018. Overall survival (OS), disease-free survival (DFS), local control (LC), and radiation-related toxicities were determined.

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Background And Purpose: To determine the neck management of tongue cancer, this study attempted to construct an artificial neural network (ANN)-assisted model based on computed tomography (CT) radiomics of primary tumors to predict neck lymph node (LN) status in patients with tongue squamous cell carcinoma (SCC).

Materials And Methods: Three hundred thirteen patients with tongue SCC were retrospectively included and randomly divided into training (60%), validation (20%) and internally independent test (20%) sets. In total, 1673 feature values were extracted after the semiautomatic segmentation of primary tumors and set as input layers of a classical 3-layer ANN incorporated with or without clinical LN (cN) status after dimension reduction.

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Article Synopsis
  • * Researchers synthesized new SDH inhibitors by using the C-Si switch strategy, resulting in several derivatives with improved fungicidal activity against SDH, outperforming the original compound flubeneteram and other controls in tests.
  • * Greenhouse and field trials demonstrated that a specific compound with trimethyl-silyl substitution showed comparable or superior fungicidal effects against soybean rust at lower concentrations compared to established fungicides, confirming the C-Si strategy’s effectiveness in developing new
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Objective: To retrospectively review the impact of the outbreak of coronavirus disease 2019 (COVID-19) on services in the oral emergency room.

Materials And Methods: A statistical analysis of epidemiological characteristics and the patients' diagnoses and treatments in the Emergency Department of Peking University Hospital of Stomatology during the outbreak of COVID-19 in 2020 compared with those in 2019 in Beijing, China.

Results: There were fewer total visits in 2020 than in 2019 (P = 0.

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Objective: The aim of this study was to investigate the effectiveness and safety of surgery combined with I seed brachytherapy for treatment of carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland and to identify the factors associated with prognosis.

Study Design: We conducted a retrospective analysis of data of patients with CXPA of the parotid gland treated with surgery plus I seed brachytherapy at the Peking University School of Stomatology Hospital between December 2003 and July 2018.

Results: Fifty-five patients (median age, 51 years) were included in the study.

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Armadillo gene subfamily members (ARMCX1-6) are well-known to regulate protein-protein interaction involved in nuclear transport, cellular connection, and transcription activation. Moreover, ARMCX signals on cell pathways also implicated in carcinogenesis and tumor progression. However, little is known about the associations of the ARMCX subfamily members with gastric carcinoma.

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Background: Acinic cell carcinoma (AciCC) is rare in children; therefore, reaching a consensus on its management is challenging and radiotherapy is limited by concerns about long-term toxicity. The purpose of this study is to analyze the effectiveness and safety of surgery plus postoperative I interstitial brachytherapy (IBT) for children and adolescents with AciCC of the parotid gland (PG) treated at a single institution.

Procedure: Sixteen patients ≤ 18 years old with AciCC of the PG treated with surgery plus I IBT from 2007 to 2018 were included.

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Purpose: The aim of this study was to evaluate the feasibility and diagnostic accuracy of core needle biopsy (CNB) in patients with focal fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) in deep regions of the head and neck, with the guidance of infrared navigation integrated with PET.

Materials And Methods: Patients with suspected primary or recurrent malignancies of the head and neck on PET/CT, from June 2016 to December 2018, were included. Before CNB, the region of interest was delineated and the ideal needle entry points, target sites, and a number of trajectories were designed on iPlan CMF 3.

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Purpose: The aim was to evaluate the safety and efficacy of subcutaneous injection of hyaluronic acid in decreasing acute skin toxicity after adjuvant interstitial brachytherapy in parotid gland cancer patients.

Materials And Methods: Patients with histologically proven parotid gland cancer who would be treated with adjuvant interstitial brachytherapy were included in this nonrandomized controlled trial. Participants were nonrandomly divided into the experimental group and control group.

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Article Synopsis
  • The study evaluated the prognostic value of PET parameters and texture features from pretreatment PET/CT scans in patients with locally advanced salivary gland carcinoma treated with interstitial brachytherapy.
  • Forty-three patients underwent PET/CT before treatment, and 54 texture features were analyzed to predict progression-free survival (PFS).
  • Results showed that texture features, particularly minimum intensity and long run emphasis, were better predictors of PFS compared to conventional PET parameters and clinicopathological factors.
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Background: This study aimed to determine the effectiveness and safety of surgery combined with postoperative I seed brachytherapy for treatment of primary mucoepidermoid carcinoma (MEC) of the parotid gland.

Methods: Retrospective analysis of data of patients with MEC (n = 108) treated with surgery plus postoperative I seed brachytherapy between 2004 and 2016. Overall survival (OS), disease-free survival (DFS), local control rate (LCR), distant metastasis, and radiation-associated toxicities were analyzed, and factors affecting outcomes were evaluated.

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Purpose: Adenoid cystic carcinoma (ACC) involving the skull base is difficult to treat and sometimes unresectable. The purpose of this study was to evaluate the efficacy and safety of I radioactive seed interstitial brachytherapy for treatment of these patients.

Materials And Methods: Patients with ACC involving the skull base treated by definitive I brachytherapy from March 2008 through December 2018 at the Peking University Hospital of Stomatology (Beijing, China) were retrospectively identified.

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The complete genome sequence of Morganella morganii DG56-16 was sequenced. This strain was isolated from the liver of a dead crocodile lizard (Shinisaurus crocodilurus). The genome size was 3.

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Article Synopsis
  • Researchers wanted to see if using computers could help doctors place tiny radiation needles accurately in deep areas of the head and neck.
  • They tested this on 10 patients with tumors, using special computer models and templates to guide the needle placement.
  • The study showed that using computers made the needle placement successful and accurate, which is good for treating those patients.
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Austwickia chelonae, a species of Actinobacteria, is one of the pathogens that cause dermatophilosis in animals. Here, we report the complete genome sequence of Austwickia chelonae LK16-18, which was isolated from cutaneous granulomas in crocodile lizards.

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