Publications by authors named "Ming-Rui Chen"
Rationale: To date, the benefit of intravenous thrombolysis for acute ischemic stroke (AIS) patients without advanced neuroimaging selection is confined to within 4.5 h of onset. Our phase II EXIT-BT (Extending the tIme window of Thrombolysis by ButylphThalide up to 6 h after onset) trial suggested the safety, feasibility, and potential benefit of intravenous tenecteplase (TNK) in AIS between 4.
View Article and Find Full Text PDFObjective: This study aimed to develop a nomogram tool to predict cerebral white matter lesions (WMLs) in elderly men.
Methods: Based on a retrospective cohort from January 2017 to December 2019, a multivariate logistic analysis was performed to construct a nomogram for predicting WMLs. The nomogram was further validated using a follow-up cohort between January 2020 and December 2022.
To date, the benefit of intravenous thrombolysis is confined to within 4.5 h of onset for acute ischemic stroke (AIS) without advanced neuroimaging selection. The current trial aimed to investigate the safety and efficacy of intravenous tenecteplase (TNK) plus Dl-3-n-Butylphthalide (NBP) in AIS within 4.
View Article and Find Full Text PDFRecently, an increasing number of studies have shown that long noncoding RNAs (lncRNAs) are involved in host metabolism after infection with pseudorabies virus (PRV). In our study, via RNA sequencing analysis, a total of 418 mRNAs, 137 annotated lncRNAs, and 312 new lncRNAs were found to be differentially expressed. These lncRNAs were closely associated with metabolic regulation and immunity-related signalling pathways, including the T-cell receptor signalling pathway, chemokine signalling pathway, mitogen-activated protein kinase (MAPK) signalling pathway, TNF signalling pathway, Ras signalling pathway, calcium signalling pathway, and phosphatidylinositol signalling system.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates whether using intra-arterial tenecteplase (TNK) during the first attempt at endovascular treatment (EVT) improves outcomes for patients with acute ischemic stroke due to large vessel occlusion (LVO).
- The BRETIS-TNK trial enrolled 26 patients and found that the rate of successful reperfusion was higher in the TNK group compared to a historical control group, especially after adjusting for other factors.
- Additionally, the trial suggests TNK administration is safe, with similar rates of complications, and there's potential for better functional independence at 90 days post-treatment.
Article Synopsis
- Endovascular treatment (EVT) is the preferred method for treating acute ischemic stroke caused by large vessel occlusion (LVO), allowing for analysis of blood contents from the affected areas.
- A study of 45 LVO patients undergoing EVT found notable alterations in blood gas values and electrolytes, particularly K+, Ca2+, and pH levels before and after the procedure, which may help predict patient outcomes.
- Results indicated that specific changes in these blood parameters, especially the proximal/femoral ratios of pH and Na+, correlate with clinical improvements within 72 hours post-treatment, highlighting the potential for these metrics in assessing stroke recovery.
[Correction of shortened and broaden prolabium deformity with double flag-shaped flaps following bilateral cleft lip repair].
Zhonghua Zheng Xing Wai Ke Za Zhi
July 2013
Objective: To explore the correction for shortened and broaden prolabium deformity following bilateral cleft lip repair.
Methods: We designed the upper lip double flag-shaped flaps. The quadrilateral original surgical scar (flap flag pole part) was resected and the incision was made along the direction of nasolabial groove at the nostrils bottom to form two flag-shaped flaps (the section of the flag face).
[Gene expression of transforming growth factor beta receptor II in the epidermis of pathological scar].
Zhonghua Shao Shang Za Zhi
August 2012
Article Synopsis
- The study aimed to investigate the expression of the TbetaR II gene in pathological scars from burn or trauma patients.
- Twenty pathological scar samples were compared with normal skin samples from the same patients and additional controls to analyze gene expression through various techniques, including PCR.
- Results indicated lower levels of TbetaR II in pathological scars compared to normal skin, with abnormal patterns found in some samples, suggesting a potential link between TbetaR II expression and scarring.
[Repairing soft-tissue defection of ankle and foot by sural neurovascular pedicle fasciocutaneous reversed island flap].
Zhonghua Zheng Xing Wai Ke Za Zhi
September 2005
Objective: To explore the clinical application of sural neurovascular pedicle fasciocutaneous reversed island flap to repair soft-tissue defection of the ankle and foot.
Methods: From Sep. 1994 to Oct.