Publications by authors named "Ming-Qi Yan"
Article Synopsis
- Mitochondria play key roles in various cellular processes, including energy production and cell growth, with a specific focus on the protein mitoguardin (Miga) and its importance in ovarian development.* -
- The study found that MIGA1 and MIGA2 promote ovarian granulosa cell proliferation and influence the activity of the protein YAP1 through the Hippo signaling pathway, particularly noting the effects of MIGA2.* -
- MIGA2's regulation of YAP1 activity and the interaction with lysophosphatidic acid (LPA) and AKT activity may shed light on reproductive endocrine diseases like polycystic ovary syndrome (PCOS).*
Polycystic ovary syndrome (PCOS) is an endocrinopathy characterized by hyperandrogenism, anovulation, and polycystic ovaries, in which hyperandrogenism manifests by excess androgen and other steroid hormone abnormalities. Mitochondrial fusion is essential in steroidogenesis, while the role of mitochondrial fusion in granulosa cells of hyperandrogenic PCOS patients remains unclear. In this study, mRNA expression of mitochondrial fusion genes mitoguardin1, -2 () was significantly increased in granulosa cells of hyperandrogenic PCOS but not PCOS with normal androgen levels, their mRNA expression positively correlated with testosterone levels.
View Article and Find Full Text PDFGlobal transcriptional activity increases as oocytes grow and is silenced in fully grown oocytes. Thus, the chromatin configuration varies during oocyte growth, but the molecular mechanisms regulating these changes remain to be clarified. Here, we studied a susceptibility gene of polycystic ovary syndrome (PCOS), RPS26, which is a ribosomal protein-encoding gene that is highly expressed in the ovary, but the functions of which remain unknown.
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