Publications by authors named "Ming-Pu Sun"
Article Synopsis
- Cytotoxic peptides from spider venoms, like LVTX-8 from Lycosa vittata, show promise for cancer treatment but have stability issues due to protease degradation.
- Ten analogs of LVTX-8 were synthesized, with several showing high cytotoxicity against cancer cells that is comparable to or better than the natural peptide.
- Modifications to LVTX-8 improved its stability and efficacy, with derivatives 825 and 827 demonstrating enhanced anticancer properties and potential as leads for drug development.
