Synthesis, crystal structure and bioactivities of α-asaronol.

α-Asaronol [or (E)-3'-hydroxyasarone; systematic name: (E)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-ol; CHO] was synthesized towards the development of a potential antiepileptic drug. Following purification by recrystallization, single crystals of α-asaronol were obtained by a liquid interface diffusion method at room temperature. The product was characterized by H and C NMR, and FT-IR spectroscopic analysis.

Ligand-free copper-catalyzed C(sp)-H imidation of aromatic and aliphatic methyl sulfides with -fluorobenzenesulfonimide.

A novel and efficient process has been developed for copper-catalyzed C(sp)-H direct imidation of methyl sulfides with -fluorobenzenesulfonimide(NFSI). Without using any ligands, various methyl sulfides including aromatic and aliphatic methyl sulfides, can be transformed to the corresponding -((phenylthio)methyl)-benzenesulfonamide derivatives in good to excellent yields.