Publications by authors named "Ming-Luan Zhao"
Objective: Though an increased risk of atherosclerosis is associated with anti-CTLA-4 antibody therapy, the underlying mechanisms remain unclear.
Methods: C57BL/6 mice were treated with anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibody twice a week for 4 weeks, after being injected with AAV8-PCSK9 and fed a Paigen diet (PD). The proportion of aortic plaque and lipid accumulation were assessed using Oil Red O staining, while the morphology of atherosclerotic lesions was analyzed with hematoxylin and eosin staining.
Article Synopsis
- Scientists studied how a special antibody, called anti-CTLA-4, affects the heart when treating cancer, and found it can make heart problems worse.
- They used mice with heart issues and gave them this antibody, which led to even more heart damage and inflammation.
- The research suggests that blocking certain signals in the body might help prevent heart problems caused by this cancer treatment.