Inhibition of SMP30 gene expression influences the biological characteristics of human Hep G2 cells.

Senescence marker protein 30 (SMP30), a hepatocellular carcinoma (HCC) associated antigen had been identified by our research group. To study its mechanisms of regulation and associations with the occurrence and development of HCC, we inhibited expression by RNAi technique, and observed effects on the biological characteristics of Hep G2 cells. In cell viability assays, cell growth in the experimental group (with siRNA transfection) was elevated.