Publications by authors named "Ming-Juan Du"
Article Synopsis
- Adult stem cells are crucial for keeping tissues healthy, but the presence of these cells in human minor salivary glands is not well-studied.* -
- Researchers successfully isolated human minor salivary gland mesenchymal stem cells (hMSGMSCs) that can self-renew and differentiate into various cell types, showing both embryonic and mesenchymal stem cell characteristics.* -
- When hMSGMSCs were transplanted into mice, they survived and showed signs of integrating into the liver, indicating potential for use in cell therapy and regenerative medicine.*
Vav1, a guanine nucleotide exchange factor (GEF) for Rho family GTPases, is a hematopoietic protein involved in a variety of cellular events. In recent years, aberrant expression of Vav1 has been reported in non-hematopoietic cancers including human breast cancer. It remains to be answered how Vav1 is expressed and what Vav1 does in its non-resident tissues.
View Article and Find Full Text PDFVav1 is a guanine nucleotide exchange factor (GEF) specifically expressed in hematopoietic cells. It consists of multiple structural domains and plays important roles in T cell activation. The other highly conserved isoforms of Vav family, Vav2 and Vav3, are ubiquitously expressed in human tissues including lymphocytes.
View Article and Find Full Text PDFAim: To investigate a novel function of proto-oncogene Vav1 in the apoptosis of human leukemia Jurkat cells.
Methods: Jurkat cells, Jurkat-derived vav1-null cells (J.Vav1) and Vav1-reconstituted J.