Publications by authors named "Ming-Jian Lu"
Endoplasmic reticulum (ER) stress and unfolded protein response are cells' survival strategies to thwart disruption of proteostasis. Tumor cells are continuously being challenged by ER stress. The prion protein, PrP, normally a glycosylphosphatidylinositol (GPI)-anchored protein exists as a pro-PrP retaining its GPI-peptide signal sequence in human pancreatic ductal cell adenocarcinoma (PDAC).
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- The study aimed to assess the effectiveness and safety of lobaplatin-transcatheter arterial chemoembolization (TACE) combined with radioactive 125I seed implantation for treating primary hepatocellular carcinoma (HCC).
- A total of 75 patients participated, with 43 undergoing TACE alone and 32 receiving the combined treatment; results showed improved disease control and survival rates in the TACE+125I group compared to TACE alone.
- The findings indicate that the combination treatment is both effective and safe, with no serious complications reported, making it a promising option for HCC management.
Experimental research on a novel iodine-125 seed strand connected using magnesium alloy AZ31.
Recent Pat Anticancer Drug Discov
May 2014
Background And Purpose: Aim of this research is to study the in vivo degradation and biocompatibility in rabbits and the dose distribution of novel iodine-125 seed strands connected using magnesium alloy AZ31.
Method: Thirty-three New Zealand rabbits were divided into three Groups (A, B, and C). All rabbits in Groups A and C were implanted with VX2 tumors.
Background & Objective: What damages 125Iodine (125I) seed implantation will do to normal tissue is an observation topic in clinic. This study was to investigate the impact of 125I seed implantation to the femoral arteries of rabbits.
Methods: A total of 30 healthy rabbits were divided into 3 groups.
Objective: To investigate the clinical value of CT-guided radioactive seed (125)I implantation in treating recurrence and metastasis after liver transplantation in hepatoma.
Methods: Eleven patients with recurrence and metastasis after liver transplantation for hepatoma, with 45 metastatic lesions, 2.5 cm in diameter on average totally 9 males and 2 females, aged 56 (35 approximately 68), underwent CT-guided radioactive seed 125I implantation for 33 man-times.
[CT guided radioactive seed 125I implantation in treatment of pancreatic cancer].
Zhonghua Yi Xue Za Zhi
January 2006
Objective: To investigate the clinical value of CT guided radioactive seed (125)I implantation in treatment of pancreatic cancer.
Methods: Twenty-six patients with pancreatic cancer 6.1 cm in size on average, 21 males and 5 females, aged 60 +/- 13 (47 - 73), underwent CT guided radioactive seed (125)I implantation.