[Advantages and application prospects of model organism Drosophila in modern research of traditional Chinese medicine].

Traditional Chinese medicine(TCM) is widely used to prevent and treat various diseases due to its many active ingre-dients, diverse biological activities, low side effects, and drug resistance. The classical model organism Drosophila melanogaster, with its advantages of short life cycle, simple physiological structure, low cultivation cost, and easy operation, has been widely used in the modern research of TCM through gene regulation techniques including transgenic and gene knockout techniques. In this paper, the application of Drosophila in modern research of TCM was outlined from the disease models of inflammatory bowel disease, aging, tumor, neurodegenerative disease, and sleep disorders, with a view to providing new methods and techniques for the research and application of the model organism Drosophila in the field of TCM.

[Molecular mechanism of sleep deprivation-induced body injury and traditional Chinese medicine prevention and treatment: a review].

Sleep occupies one-third of a person's lifetime and is a necessary condition for maintaining physiological function and health. With the increase in social and economic pressures, the growing use of electronic devices and the accelerated aging process of the population, insufficient sleep and its hazards have drawn widespread attention from researchers in China and abroad. Sleep deprivation refers to a decrease in sleep or a severe lack of sleep due to various reasons.

[Research progress on Astragali Radix and prediction of its quality markers (Q-markers)].

Astragali Radix, a medicinal herb for invigorating Qi, has anti-aging, anti-tumor, immunoregulatory, blood sugar-and lipid-lowering, anti-fibrosis, anti-radiation and other pharmacological effects. This article reviewed the studies about the chemical components and pharmacological effects of Astragali Radix. According to the theory of quality markers(Q-markers) of Chinese medicinal materials, we predicted the Q-markers of Astragali Radix from traditional efficacy, chemical component validity, measurability, plant phylogeny, and pharmacokinetis.

Intracerebroventricular administration of apelin-13 inhibits distal colonic transit in mice.

Apelin is a novel bioactive peptide as the endogenous ligand for the orphan G-protein-coupled receptor (GPCR), APJ, a receptor distributed in various tissues such as the hypothalamus and the gastrointestinal tract. Recent reports showed that apelin regulated many biological functions, including blood pressure, neuroendocrine, drinking behavior and food intake. However, the role of apelin in regulating gastrointestinal motility remains unknown.