Publications by authors named "Ming-Hon Hsu"
Background: Human endogenous retroviruses (HERVs) play an important role in the development of cancer and many diseases. Here, we comprehensively explored the impact of HERVs on hepatocellular carcinomas (HCCs).
Methods: We employed Telescope to identify HERVs and quantify their expression in the total RNA sequencing data obtained from 254 HCC samples, comprising 254 tumor tissues and 34 matched normal tissues.
Article Synopsis
- * Key findings highlight the most frequently mutated cancer-related genes (TERT, TP53, CTNNB1, RB1, ARID1A) and their correlation with patient survival, etiology of HCC, and various clinicopathological conditions.
- * The research also uncovers significant associations between genomic alterations, immune checkpoint gene expression, and the tumor microenvironment, which could lead to improved diagnosis and treatment strategies for HCC.
Background: Genomic alterations play important roles in the development of cancer. We explored the impact of protein-coding genes and transcriptomic changes on clinical and molecular alterations in Taiwanese hepatocellular carcinoma (HCC) patients.
Methods: We analyzed 147 whole-exome sequencing and 100 RNA sequencing datasets of HCC and compared them with The Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma cohort and develop a panel of 81 apoptosis-related genes for molecular classification.