Stable Ethosome-like Catanionic Vesicles for Transdermal Hydrophilic Drug Delivery with Predictable Encapsulation Efficiency.

Lipid-like pseudo-double-chained catanionic surfactants have emerged as the attractive materials to prepare potential vesicular carriers in drug and gene delivery applications. In particular, the semi-spontaneous process has been developed to fabricate ethosome-like catanionic vesicles for the transdermal drug delivery. In this work, Arbutin (a water-soluble drug) encapsulation efficiency of ethosome-like catanionic vesicles fabricated from decyltrimethylammonium-tetradecylsulfate (DeTMA-TS, CH(CH) N(CH)-CH(CH)SO) and decyltrimethylammonium-dodecylsulfate (DeTMA-DS, CH(CH)N(CH)-CH(CH)SO) with various amounts of ethanol and cholesterol in tris buffer solution was experimentally determined.