Publications by authors named "Ming-An Yu"
Changes in thyroid function after thermal ablation of thyroid nodules.
Front Endocrinol (Lausanne)
March 2025
Purpose: To evaluate changes in thyroid function post-thermal ablation (TA) of thyroid nodules and to identify risk factors associated with post-ablation thyroid function abnormalities.
Materials And Methods: A retrospective analysis of 2,264 cases treated with TA between June 2015 and July 2024 was conducted, including 1,169 benign thyroid nodules (BTNs) and 1,095 papillary thyroid carcinoma (PTC) cases. Thyrotropin (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured before treatment and at 1, 3, 6, 9, and 12 months post-ablation.
Objectives: To evaluate the efficacy and safety of thermal ablation (TA) for follicular thyroid neoplasms (FTN) ≤ 3 cm.
Methods: This retrospective multicenter study enrolled 161 patients (131 females; mean age, 46 ± 15 years [range, 11-86]) who underwent TA for FTN ≤ 3 cm between January 2014 and October 2023 from eight centers in China. The median follow-up time was 12 months (IQR, 12-24 months).
Rationale And Objectives: This study aimed to analyze risk factors influencing disease progression in patients with papillary thyroid cancer (PTC) undergoing microwave ablation (MWA).
Materials And Methods: In this retrospective single-center study, 889 patients (647 women; median age, 40 years; age range, 14-80 years) who underwent MWA for PTC from June 2015 to December 2022 were enrolled. A least-absolute shrinkage and selection operator Cox regression model was employed to identify important factors for disease progression.
Objective: We conducted the systematic review and meta-analysis to comprehensively compare ablation and surgery in terms of effectiveness, safety and multiple factors affecting life quality of patients with papillary thyroid cancer (PTC).
Methods: PubMed, Embase, Scopus, Web of Science and EBSCO were searched for relevant studies published between January 1980 and September 2023. Two reviewers independently extracted data according to the PRISMA recommendations and assessed the quality of each study with the Cochrane Risk of Bias Tool.
Objective: The present study aimed to analyze the relationship between the incidence of complications and tumor size following thermal ablation of benign thyroid nodules (BTNs).
Methods: In this retrospective study, 1198 patients who underwent thermal ablation for unifocal BTN were enrolled. Receiver Operating Characteristic analysis was performed to select the cutoff values of the maximum diameter (MD) for dividing patients into different groups or subgroups.
To evaluate the feasibility, safety and efficiency of the microwave ablation (MWA) of T1N0M0 papillary thyroid carcinoma (PTC) locating in dangerous region. This is a clinical retrospective study, and the data of patients who underwent thermal ablation for T1N0M0 PTC from June 2016 to March 2021 were reviewed. After ablation, the rates of technical success, as well as the changes in tumor size and volume, tumor disappearance, disease progression, and complications, were assessed.
View Article and Find Full Text PDFThis study aims to examine the ultrasonic characteristics of perithyroid fascial spaces following in vivo hydrodissection, validating their visualization through a comparative analysis with anatomical references. A retrospective review was conducted on data from 2390 patients (631 males and 1759 females, median age 46 years, 25-75% interquartile range 26-69 years) who underwent microwave ablation for thyroid tumors, including 1436 benign nodules and 954 papillary thyroid carcinomas. Detailed descriptions of perithyroid fascial spaces and the hydrodissection strategy were provided.
View Article and Find Full Text PDFObjective: To evaluate the feasibility, safety, and efficacy of microwave ablation (MWA) for the treatment of patients with Bethesda IV follicular neoplasms (FNs) (≤3 cm).
Methods: In the retrospective study, patients who underwent MWA for Bethesda IV follicular neoplasms (≤3 cm) were included. Technical success, volume reduction, disease progression, and adverse event (AE) rates were analyzed postablation.
Background Interest in microwave ablation (MWA) and radiofrequency ablation (RFA) use for treating secondary hyperparathyroidism (SHPT) is rising; however, ablation outcomes in patients with SHPT are not well characterized. Purpose To assess the response of parathyroid hormone (PTH), calcium, phosphorus, and alkaline phosphatase (ALP) levels to US-guided parathyroid MWA and RFA and the safety of these treatments in participants with SHPT. Materials and Methods This prospective multicenter cohort study, conducted from September 2017 to March 2022, included participants with SHPT.
View Article and Find Full Text PDFBackground: Thyroid nodule rupture (TNR) is a rare and severe complication after thermal ablation (TA), mostly from benign thyroid nodules (BTN).
Objective: To summarize the incidence of TNR after TA and analyze the causes and prevention strategies.
Materials And Methods: This retrospective study enrolled 3971 patients who underwent TA for BTN from January 2014 to March 2024.
The Chinese guidelines for ultrasound-guided thermal ablation of thyroid nodules (2024 edition) were jointly initiated by the Ultrasound Committee of Chinese Medical Association, the Interventional Ultrasound Committee of Chinese Association of Ultrasound in Medicine and Engineering, the Ultrasonic Intervention Committee of Chinese Colleges of Interventionalists, and the Oncological Intervention Committee of Chinese Research Hospital Association; 37 multidisciplinary experts in interventional ultrasound, ultrasound medicine, endocrinology, and thyroid surgery participated in the compilation of this guide, which expanded the depth and breadth of the perspective and enhanced the authority of the guide. Based on the systematic review of literature related to ultrasound-guided thermal ablation of thyroid nodules and the professional opinions of experts, the guidelines define the indications and contraindications of thermal ablation, including pre-ablation evaluation and preparation, thermal ablation techniques and operational procedures, post-ablation follow-up, therapeutic effect evaluation, complication prevention and treatment, and the writing of medical documents for ablation. According to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE), a total of 17 objective and comprehensive recommendations were given.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess how different levels of thyroid-stimulating hormone (TSH) affect tumor progression and survival in patients with early-stage papillary thyroid cancer treated with microwave ablation (MWA).
- It analyzed the medical records of 525 patients, categorizing them into uni-focal (U-PTC) and multifocal (M-PTC) groups based on TSH levels after treatment, and observed the rates of tumor progression and survival outcomes.
- Results indicated that lower TSH levels in U-PTC patients correlated with higher tumor progression rates and reduced progression-free survival compared to medium and high TSH levels, whereas M-PTC patients showed no significant relationship between TSH levels and progression.
Objectives: This study aimed to evaluate the long-term efficacy and safety of microwave ablation (MWA) for solitary T1N0M0 papillary thyroid carcinoma (PTC) and compare them between T1a and T1b disease.
Materials And Methods: This retrospective study included 136 patients with solitary T1N0M0 PTC who were treated with MWA and followed up for more than 5 years. Outcomes were compared between patients with T1a and T1b disease.
Article Synopsis
- Thermal ablation (TA) is an effective treatment for benign thyroid nodules (BTNs), but the study seeks to determine the optimal maximum diameter (MD) for effective results.
- Analyzing data from 639 BTNs, the study finds that the complete disappearance rate is significantly linked to the MD, with an optimal threshold identified at 25.0 mm.
- Results show that BTNs larger than 25.0 mm have a lower chance of complete disappearance and a higher rate of complications compared to smaller nodules.
Article Synopsis
- The study aimed to evaluate the feasibility, efficacy, and safety of microwave ablation for treating follicular thyroid neoplasms.
- It involved 74 patients, achieving a 100% technical success rate and significant reduction in nodule size and volume over 24 months, with no adverse changes in thyroid function.
- Results indicate that microwave ablation is an effective and safe treatment option, with low rates of recurrence and complications.
Article Synopsis
- This study examined risk factors for recurrent laryngeal nerve (RLN) injury after microwave ablation (MWA) of thyroid nodules and recovery time for hoarseness post-procedure.
- The analysis included 1,216 patients from five hospitals, focusing on nodule characteristics and their impact on hoarseness, particularly the distance from nodules to the tracheoesophageal groove (TEG-D) and posterior capsule distance (PCD).
- Findings showed that closer nodules (TEG-D ≤ 2 mm) correlated with longer recovery times from hoarseness, highlighting TEG-D as a crucial risk factor for both injury and recovery in MWA procedures.
Objective: To evaluate the efficacy and safety of thermal ablation in treating solitary low-risk T2N0M0 papillary thyroid cancer (PTC) and compare the outcomes of microwave ablation (MWA) and radiofrequency ablation (RFA).
Materials And Methods: This retrospective, single center study involved 34 patients (age: 40.0 ± 13.
Article Synopsis
- * A retrospective analysis of 280 TR5 nodules revealed that larger nodules (MD ≥ 6.2 mm) were more likely to yield probably malignant (PM) outcomes compared to smaller ones, with a significant difference in MD between PM and probably benign (PB) groups.
- * The findings suggest that an MD threshold of 6.2 mm is optimal for deciding when to perform FNA in TR5 nodules, as larger nodules have a higher probability
Background Microwave ablation (MWA) is currently under preliminary investigation for the treatment of multifocal papillary thyroid carcinoma (PTC) and has shown promising treatment efficacy. Compared with surgical resection (SR), MWA is minimally invasive and could preserve thyroid function. However, a comparative analysis between MWA and SR is warranted to draw definitive conclusions.
View Article and Find Full Text PDFObjective: To evaluate the complications associated with microwave ablation (MWA) in treating persistent/recurrent hyperparathyroidism (HPT) post-surgical or ablative treatments.
Materials And Methods: From January 2015 to December 2022, 87 persistent/recurrent HPT patients (primary HPT [PHPT]: secondary HPT [SHPT] = 13:74) who underwent MWA after surgical or ablative treatment were studied. Grouping was based on ablation order (initial vs.
Rationale And Objectives: To evaluate the feasibility, efficiency, and safety of microwave ablation (MWA) for multifocal papillary thyroid microcarcinoma (PTMC).
Methods: This was a retrospective study, and the data of patients who underwent MWA for multifocal PTMC from October 2016 to December 2021 were reviewed. After ablation, the changes in tumor size and volume, as well as the rates of technical success, tumor disappearance, disease progression, and complications, were assessed.
Article Synopsis
- - The study aims to compare the health-related quality of life (HRQoL) between patients with T1N0M0 papillary thyroid carcinoma who underwent microwave ablation (MWA) and those who had total thyroidectomy (TT).
- - Researchers analyzed 180 patients, equally divided into two groups, using quality of life questionnaires (EORTC QLQ-C30 and THYCA-QoL) to assess HRQoL scores.
- - Results showed that the MWA group had significantly better quality of life scores in multiple areas compared to the TT group, suggesting MWA could be a favorable alternative to TT for these patients.
Article Synopsis
- Microwave ablation (MWA) shows comparable effectiveness and safety to surgery for treating T1bN0M0 papillary thyroid carcinoma (PTC), offering a minimally invasive option.
- In a study involving 123 patients, those undergoing MWA had similar outcomes to those who chose surgery, with little difference in local tumor progression and complications.
- MWA resulted in better cosmetic results, suggesting it could be a viable alternative for low-risk PTC, though more research is needed regarding lymph node metastasis concerns.
Article Synopsis
- The study aimed to evaluate the safety of a new hydrodissection technique during microwave ablation (MWA) for secondary hyperparathyroidism (SHPT) by comparing improved hydrodissection to traditional methods.
- Data from 337 patients revealed that the risk of hoarseness, a common complication from nerve injury, was significantly lower in the improved hydrodissection group (6.9%) versus the traditional group (13.0%).
- Additionally, patients in the improved group recovered from hoarseness in a median time of 2 months compared to 6 months for those in the traditional group, suggesting the improved technique is safer without compromising technical effectiveness.
Article Synopsis
- The study investigates the safety and efficacy of microwave ablation (MWA) in patients with multifocal papillary thyroid carcinoma (M-PTC) compared to those with unifocal papillary thyroid carcinoma (U-PTC), using data from 504 patients over five years.
- Results showed that while the complete ablation was achieved in all cases, the tumour disappearance rate was significantly lower and slower for M-PTC patients compared to U-PTC, but the overall safety and complication rates were comparable between the two groups.
- In conclusion, MWA is an effective and safe treatment for selected M-PTC patients, with clinical outcomes similar to those with U-PTC