EWSR1/FUS::TFCP2-rearranged rhabdomyosarcoma (RMS) is a rare tumor with an aggressive clinical course, a predilection for craniofacial bones, spindled and/or epithelioid histomorphology, and positive immunohistochemistry (IHC) for epithelial and myogenic markers, along with variable ALK expression. Herein, we present four additional cases of primary cutaneous TFCP2-rearranged RMS. Notably, one tumor (case 1) displayed a varied pathological spectrum, initially presenting as a low-grade spindle cell neoplasm, but progressed into a high-grade spindle/epithelioid tumor.
View Article and Find Full Text PDFThe conserved role of juvenile hormone (JH) signals in preventing larvae from precocious metamorphosis has been confirmed in insects. Crustaceans have different metamorphosis types from insects; we previously proved that methyl farnesoate (MF) can prohibit larvae metamorphosis in mud crabs, but the molecular signal of this process still needs to be elucidated. In this study, () of was obtained and characterized, which we named .
View Article and Find Full Text PDFBackground: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Accurate risk stratification is essential for optimizing treatment strategies. A 14-gene RNA-level assay of lung cancer, which involves quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis of formalin-fixed paraffin-embedded (FFPE) tissue samples, offers a promising approach.
View Article and Find Full Text PDFBackground: Unique features and worse outcomes have been reported for breast cancers among adolescents and young adults (AYAs; age 15-39 years). However, there are few up-to-date and comprehensive data to analyze the disease burden of AYA breast cancer.
Patients And Methods: The data of incidence, deaths, and disability-adjusted life years (DALYs) owing to breast cancer was obtained from the Global Burden of Disease (GBD) 2021.
Cell Mol Immunol
December 2024
Systemic lupus erythematosus (SLE) is a complex, multiorgan autoimmune disorder. Although it is widely believed that SLE originates from immune cell dysregulation, the etiology of SLE is not yet clear. Here, we propose a new theory in which SLE can be directly initiated by molecular alterations in keratinocytes rather than immune cells.
View Article and Find Full Text PDFAlthough the current nanozymes, such as FeO nanoparticles, exhibit biocatalytic activities, they dramatically differ from natural enzymes, lacking a degradable organic framework and an intrinsically flexible structure. Single-chain folding of a synthetic polypeptide by metal coordination can mimic metalloproteins more similarly. A triblock PEG-polypeptide copolymer, poly(ethylene glycol)--poly(but-3-yn-1-yl glutamate)--poly(-butyl glutamate) [EG(Glu-yne)(Glu-tBu)], was synthesized by NCA polymerization.
View Article and Find Full Text PDFAn Fe-doped Ni-based oxalate framework, synthesized a facile co-precipitation method, is applied as an excellent bi-functional electrocatalyst for water and urea oxidation reactions. The obtained framework achieved a large current density of 100 mA cm at 1.497 V and 1.
View Article and Find Full Text PDFThe solid phase byproduct obtained after conventional fucoidan extraction from the brown seaweed can be used as a source containing alginate. This study involves ultrasound-assisted extraction (UAE) of alginate from the byproduct using sodium bicarbonate. Response surface methodology (RSM) was applied to obtain the optimum conditions for alginate extraction.
View Article and Find Full Text PDFBackground: Helicobacter pylori (Hp) infection and metabolic syndrome (MetS) have a high prevalence of co-morbidities and both pose a significant threat to human health and survival. It has been suggested that Hp infection affects the development of MetS in the host, but the causal relationship between the two has not been confirmed.
Methods: We conducted a two-sample Mendelian randomization study to investigate the causal effect of Hp infection with MetS and its components.
Background: Datopotamab deruxtecan (Dato-DXd), is a humanized anti-TROP2 IgG1 monoclonal antibody linked to a potent topoisomerase I inhibitor payload (DXd). Dato-DXd has already shown antitumor activity in breast cancer; however, the determinants of response, including the importance of TROP2 expression, remain unclear. We tested the activity of Dato-DXd in a panel of breast cancer patient-derived xenografts (BCXs) varying in TROP2 expression.
View Article and Find Full Text PDFBackground: The biological process of aging plays an important role in the progress of liver fibrosis. However, epidemiological evidence about the associations between advanced fibrosis and epigenetic age acceleration (EAA) among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is limited.
Methods: We utilized publicly available DNA methylation data (GSE180474) for our analysis.
Signal Transduct Target Ther
November 2024
Oriented zinc (Zn) electrodeposition is critical for the long-term performance of aqueous Zn metal batteries. However, the intricate interfacial reactions between the Zn anode and electrolytes hinder a comprehensive understanding of Zn metal deposition. Here, the reaction pathways of Zn deposition and report the preferential formation of Zn single-crystalline nuclei followed by dense Zn(002) deposition is elucidated, which is induced by a gradient solid-electrolyte interphase (SEI).
View Article and Find Full Text PDFHook F (TWHF) is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus (SLE), with triptolide (TP) as its main active ingredient. However, its side effects also induced by TP, especially hepatotoxicity and reproductive toxicity, largely limit its application in a subset of patients. Monoclonal antibodies (mAbs) developed for the treatment of SLE that deplete B cells by targeting B cell-expressing antigens, such as CD19, have failed in clinical trials, partly due to their poor efficacy in consuming B cells.
View Article and Find Full Text PDFMacroporous resin was used to enrich flavonoids in the ethyl acetate extract of Artemisia Selengensis Turcz. Based on a single factor experiment, the enrichment process was optimized using the response surface method. The optimal parameters of the enrichment process were a sample concentration of 0.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is characterized by immune dysregulation, with neutrophil infiltration in skin lesions contributing to inflammation and disease progression. However, the interaction between fibroblasts and neutrophils in SLE skin lesions has not been fully explored. Using single-cell RNA sequencing, we identified a unique CXCL1 fibroblast subset in SLE lesions.
View Article and Find Full Text PDFPurpose: Biliary tract cancers (BTCs), which are rare and aggressive malignancies, are rich in clinically actionable molecular alterations. A major challenge in the field is the paucity of clinically relevant BTC models which recapitulate the diverse molecular profiles of these tumors. The purpose of this study was to curate a collection of patient-derived xenograft (PDX) models that reflect the spectrum of genomic alterations present in BTCs to create a resource for modeling precision oncology.
View Article and Find Full Text PDFBackground: Risk factors for recovery from oculomotor nerve palsy (ONP) after aneurysm surgery explored by meta-analysis.
Methods: The PubMed, Embase, web of science, Cochrane library, China Knowledge, Wan fang, and VIP databases were searched for case-control or cohort studies on risk factors of oculomotor nerve palsy recovery after aneurysm surgery, with a cut-off date of 14 February 2024, and data were analyzed using Stata 15.
Result: A total of 12 articles involving 866 individuals were included, meta-analysis results suggesting that gender (OR = 0.
Spectrochim Acta A Mol Biomol Spectrosc
February 2025
Hypochlorite (ClO) as a kind of highly toxic pollutant has garnered significant interest in detection methods, highlighting the pressing need to develop intelligent functional materials for the qualitative and quantitative analysis of ClO in aqueous solutions. Herein, a ratiometric fluorescent sensor was prepared by the combination of acriflavine (Acr) and UIO-66 via a post-synthetic modification strategy. Acr/UIO-66 exhibited both high crystallinity typical of metal-organic frameworks and demonstrated good fluorescent and thermal stability.
View Article and Find Full Text PDFLycium barbarum polysaccharides (LBPs) are recognized as key bioactive constituents of Lycium barbarum with diverse biological activities. However, current research on LBPs is largely confined to crude extracts, offering limited insight into the structural properties underlying their biological effects. In this study, we separated crude LBP into acidic LBP (ALBP) and neutral LBP (NLBP), which exhibited distinct physicochemical properties.
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