Publications by authors named "Ming Ying Luo"
Article Synopsis
- * The study investigates the role of Protein kinase R-like endoplasmic reticulum kinase (PERK) in LPS-induced depression-like behaviors in mice, revealing increased PERK activity in the hippocampus but not the prefrontal cortex.
- * Using the PERK inhibitor ISRIB, researchers found reduced inflammation and improved neurogenesis and depression-like behaviors, suggesting that targeting PERK could be a potential treatment for neuroinflammation-related depression.
Roles of physical exercise in neurodegeneration: reversal of epigenetic clock.
Transl Neurodegener
August 2021
The epigenetic clock is defined by the DNA methylation (DNAm) level and has been extensively applied to distinguish biological age from chronological age. Aging-related neurodegeneration is associated with epigenetic alteration, which determines the status of diseases. In recent years, extensive research has shown that physical exercise (PE) can affect the DNAm level, implying a reversal of the epigenetic clock in neurodegeneration.
View Article and Find Full Text PDFEndocrine dysfunction is known to occur after traumatic brain injury. The purpose of this study was to examine the incidence of various endocrine dysfunctions after a stroke. The Taiwan National Health Insurance Research Database (NHIRD) was searched from 2001 to 2011 for patients with a diagnosis of stroke.
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- The study aimed to analyze the distribution of vimentin (Vim) and glial fibrillary acidic protein (GFAP) in the central nervous system (CNS) of rats at different life stages: newborn, adult, and aged.
- Using confocal immunofluorescence on frozen brain and spinal cord sections from 30 healthy rats, results showed that Vim was most prominent in neuron-like cells of newborns, while GFAP levels were higher in aged rats' astrocytes.
- The co-localization of Vim and GFAP occurred mainly in the hippocampus and cerebral cortex of newborns, indicating a potential relationship between these proteins in CNS development, laying groundwork for future studies on their roles.
The aim of this study was to characterize the vascular remodeling in the external iliac artery (EIA) and the lower leg muscles in a rabbit shunt model created between the distal stump of the occluded femoral artery and the accompanying vein. Histology and immunoconfocal microscopy were used in this study. We found that: 1) both endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (P-eNOS) proteins were significantly increased in the shunt-side EIA; 2) matrix metalloproteinase-2 (MMP-2) expression was 5.
View Article and Find Full Text PDFAdipose tissue is critical in obesity and type II diabetes. Blocking of adipocyte differentiation is one of the anti-obesity strategies targeting on strong rise in fat storage and secretion of adipokine(s). However, the molecular basis of adipocyte differentiation and its regulation remains obscure.
View Article and Find Full Text PDFInnervation plays an important role in development and remodeling of blood vessels. However, very little is known whether innervation is involved in arteriogenesis. In the present study, we tested the hypothesis that innervation may contribute to the process of arteriogenesis induced by ligature of femoral artery in rat/rabbit hind limb with or without denervation.
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