Publications by authors named "Ming Yin Koo"
Article Synopsis
- A significant portion of T cells in humans can recognize lipids presented by CD1 proteins, and recent research focuses on the interaction between mycobacterial lipids and CD1c-restricted T cells, including their role in autoimmunity and cancer.
- Utilizing an artificial antigen-presenting cell (aAPC) system, researchers isolated and characterized autoreactive CD1c-restricted T cells, confirming their activation through specific recognition of endogenous lipids.
- The study identified key residues in the T cell receptor (TCR) that are crucial for autoreactivity, shedding light on the molecular characteristics and diversity of these autoreactive T cells.
