Chaos analyses of visco-hyperelastic cylindrical shells based on improved Melnikov method.

Soft-material structures have excellent characteristics of infinite degrees of freedom and large deformation, and it has important theoretical significance and application value to perform mathematical modeling and dynamic analysis. This paper studies the large-amplitude oscillation of the cylindrical shell under a harmonic excitation, where the constitutive relationship is described by the Zener rheological model based on the Rivlin-Saunders hyperelastic model. First, the Euler Lagrange equation is used to establish the nonlinear ordinary differential equation describing the radially symmetric motion of the structure, and the viscous evolution equation of the material is derived based on the rheological model, thus obtaining the governing equations of the nonlinear system.

Synergy-based Knee Angle Estimation on Stairs and Slopes for A Powered Transfemoral Prosthesis.

Above-knee amputees have difficulties in locomotion on stairs and slopes. One of the most challenging issues in controlling powered transfemoral prostheses is the design of adaptive knee trajectories for different users and terrains. The synergy-based trajectory generation approach is becoming a promising approach to solving this issue.

Characterizing sEMG changes with muscle fatigue for lower-extremity prostheses and exoskeletons control.

In powered lower limb prostheses and exoskeleton control, sEMG based methods have been widely explored and utilized due to non-invasive nature and ability to directly reflect user intentions. However, in practical use, neuromuscular fatigue (NMF) caused by long-term use can cause significant changes in sEMG signals. These issues are constraining sEMG's active prosthetics from the laboratory to real life.

Interplay between cerebral and muscular activations during motor tasks: An fNIRS-sEMG study.

Understanding the intricate relationship between brain activations and muscle activations during motor tasks is crucial for elucidating motor control mechanisms and designing effective rehabilitation strategies. In this study, we investigated this relationship using functional near-infrared spectroscopy (fNIRS) and surface electromyography (sEMG) technologies. Three healthy male subjects performed lower-limb motor tasks while their brain activations and muscle activations were recorded simultaneously.

A UOx@HMnO biozyme-nanozyme driven electrochemical platform for specific uric acid bioassays.

Uric acid (UA) is a key end product of purine metabolism in the human body, and its abnormal levels are associated with many diseases, so accurate monitoring is essential. Existing detection methods have many limitations. For example, chromatography is cumbersome, time-consuming, and not cost-effective, while serum uric acid analysis requires specialized equipment and venous blood collection.

Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure.

Background: To treat liver failure, three-dimensional (3D) bioprinting is a promising technology used to construct hepatic tissue models. However, current research on bioprinting of hepatic tissue models primarily relies on conventional single-cell-based bioprinting, where individual functional hepatocytes are dispersed and isolated within hydrogels, leading to insufficient treatment outcomes due to inadequate cell functionality.

Objective: Here, we aim to bioprint a hepatic tissue model using functional hepatocyte organoids (HOs) and evaluate its liver-specific functions and .

A Three-stage Strategy Significantly Improves Hand Movement Direction Decoding of a Single Neural Unit.

Invasive brain-computer interfaces (iBCI) can record multiple neural signals with the highest temporal and spatial resolution. However, the number of available neural units decreases with the increase in implantation time, which affects the stability of the iBCI system's control. Meanwhile, most current studies utilize a population of neural units to decode a single instruction, which limits the ability to decode multi-tasks simultaneously in complex scenarios.

TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors.

Background: Efficient tumor T-cell infiltration is crucial for the effectiveness of T-cell-based therapies against solid tumors. Eosinophils play crucial roles in recruiting T cells in solid tumors. Our group has previously generated induced eosinophils (iEOs) from human pluripotent stem cells and exhibited synergistic efficacy with CAR-T cells in solid tumor inhibition.

Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae.

Phage therapy is a promising antibacterial strategy against the antibiotic resistance crisis. The evolved phage resistance could pose a big challenge to clinical phage therapy. Therefore, it is necessary to conduct a comprehensive analysis of phage resistance mechanisms during treatment.

Application of 4D-Printed Magnetoresponsive FOGS Hydrogel Scaffolds in Auricular Cartilage Regeneration.

3D-printed hydrogel scaffolds are widely utilized in auricular cartilage tissue engineering. However, issues such as graft-related inflammation, poor mechanical properties, and the lack of external modulation of 3D-printed scaffolds in vivo have raised significant concerns. To address these challenges, a "fried egg" structure is designed, consisting of chitosan-coated ferroferric oxide magnetic nanoparticles (FeO@CS MNPs), which are uniformly incorporated into hydrogel.

Incorporating Structured and Unstructured Data Sources to Identify and Characterize Hereditary Cancer Testing Among Veterans With Metastatic Castration-Resistant Prostate Cancer.

Purpose: This study introduces an integrated approach using structured and unstructured data from an electronic health record to identify and characterize patient utilization of hereditary cancer genetic testing among patients with metastatic castration-resistant prostate cancer (mCRPC). Secondary objectives were to describe factors associated with the receipt of testing.

Methods: This retrospective cohort study included a cohort of Veterans diagnosed with mCRPC from January 2016 to December 2021.

Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZIF-8 Nanoparticles.

Background: Regenerating periodontal ligament (PDL) tissue is a vital challenge in dentistry that aims to restore periodontal function and aesthetics. This study explores a tissue engineering strategy that combines polycaprolactone (PCL)/collagen/cellulose acetate electrospun scaffolds with collagen hydrogels to deliver curcumin-loaded ZIF-8 nanoparticles fand periodontal ligament stem cells (PDLSCs).

Methods: Scaffolds were fabricated via electrospinningand collagen hydrogels incorporated PDLSCs and curcumin-loaded ZIF-8 nanoparticles (CURZIF-8) were developed using cross-linking.

Epitranscriptome profiles reveal participation of the RNA methyltransferase gene OsMTA1 in rice seed germination and salt stress response.

Background: RNA m6A methylation installed by RNA methyltransferases plays a crucial role in regulating plant growth and development and environmental stress responses. However, the underlying molecular mechanisms of m6A methylation involved in seed germination and stress responses are largely unknown. In the present study, we surveyed global m6A methylation in rice seed germination under salt stress and the control (no stress) using an osmta1 mutant and its wild type.

Narcolepsy in early childhood: a case report and a Mini review.

Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.

Effect of Heat Treatment on the Microstructure and Property of Metastable β Titanium Alloy.

TB18 is a newly developed high-strength metastable β-titanium alloy, commonly used in aerospace structural materials, which demands high mechanical performance. By altering the alloy's microstructure, heat treatment can affect its mechanical characteristics. The alloy was solution treated for one to four hours at 870 °C in order to examine the impact of solution treatment duration.

Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration.

Despite significant progress in skin wound healing, it is still a challenge to construct multifunctional bioactive dressings based on a highly aligned protein fiber coated hydrogel matrix for antifibrosis skin wound regeneration that is indistinguishable to native skin. In this study, a "dual-wheel-driven" strategy is adopted to modify the surface of methacrylated gelatin (GelMA) hydrogel with highly aligned magnetic nanocomposites-protein fiber assemblies (MPF) consisting of photothermal responsive antibacteria superparamagnetic nanocomposites-fibrinogen (Fg) complexes as the building blocks. Whole-phase healing properties of the modified hydrogel dressing, GelMA-MPF (GMPF), stem from the integration of Fg protein with RGD peptide activity decorated on the surface of the antibacterial magnetic nanoactuator, facilitating facile and reproducible dressing preparation by self-assembly and involving biochemical, morphological, and biophysical cues.

Interlimb and Intralimb Synergy Modeling for Lower Limb Assistive Devices: Modeling Methods and Feature Selection.

The concept of gait synergy provides novel human-machine interfaces and has been applied to the control of lower limb assistive devices, such as powered prostheses and exoskeletons. Specifically, on the basis of gait synergy, the assistive device can generate/predict the appropriate reference trajectories precisely for the affected or missing parts from the motions of sound parts of the patients. Optimal modeling for gait synergy methods that involves optimal combinations of features (inputs) is required to achieve synergic trajectories that improve human-machine interaction.

Distinct white matter abnormalities and cognitive impairments in deficit schizophrenia: A cross-sectional diffusion tensor imaging study.

Deficit schizophrenia (DS), characterized by persistent and primary negative symptoms, is considered a promising homogeneous subtype of schizophrenia. According to the disconnection hypothesis, abnormalities in white matter fibers are common in schizophrenia. However, comprehensive measurement of white matter metrics and exploration of the relationships between neuroanatomical changes and cognitive functions in DS patients are still unknown.

Impact of Abiotic Stress on Rice and the Role of DNA Methylation in Stress Response Mechanisms.

With the intensification of global climate change and the increasing complexity of agricultural environments, the improvement of rice stress tolerance is an important focus of current breeding research. This review summarizes the current knowledge on the impact of various abiotic stresses on rice and the associated epigenetic responses (DNA methylation). Abiotic stress factors, including high temperature, drought, cold, heavy metal pollution, and high salinity, have a negative impact on crop productivity.

RfaH contributes to maximal colonization and full virulence of hypervirulent .

Hypervirulent (hvKp) have emerged as clinically important pathogens, posing a serious threat to human health. RfaH, a transcriptional elongation factor, has been regarded as implicated in facilitating the transcription of long virulence operons in certain bacterial species. In , RfaH plays a vital role in promoting CPS synthesis and hypermucoviscosity, as well as mediating bacterial fitness during lung infection.

The impact of port green competitiveness on the hinterland economy: A case study of China.

In the global trade landscape, ports are not only critical nodes for the transportation of goods but also increasingly recognized as key factors driving sustainable development through their green competitiveness. This paper takes a green competitiveness perspective to delve into the interactive relationship between port development and the hinterland economy, aiming to provide a theoretical foundation and policy recommendations for the green development of ports. An evaluation index system for green competitiveness of ports was constructed, and a combination of the Slacks-Based Measure (SBM) and the Entropy Weighted-Technique for Order Preference by Similarity to Ideal Solution (EW-TOPSIS) method was employed to quantitatively measure and assess the 25 major coastal ports and their hinterland economic systems in China.

An Accurate Non-Contact Photoplethysmography via Active Cancellation of Reflective Interference.

Imaging Photoplethysmography (IPPG) is an emerging and efficient optical method for non-contact measurement of pulse waves using an image sensor. While the contactless way brings convenience, the inevitable distance between the sensor and the subject results in massive specular reflection interference on the skin surface, which leads to a low Signal to Interference plus Noise Ratio (SINR) of IPPG. To ease this challenge, this work proposes a novel modulation illumination approach to measure the accurate arterial pulse wave via surface reflection interference isolation from IPPG.

A Serious Game for Enhancing Rescue Reasoning Skills in Tactical Combat Casualty Care: Development and Deployment Study.

Background: Serious games (SGs) have emerged as engaging and instructional digital simulation tools that are increasingly being used for military medical training. SGs are often compared with traditional media in terms of learning outcomes, but it remains unclear which of the 2 options is more efficient and better accepted in the process of knowledge acquisition.

Objective: This study aimed to create and test a scenario-based system suitable for enhancing rescue reasoning skills in tactical combat casualty care.

Analysis of early warning indicators of death in patients with severe fever with thrombocytopenia syndrome.

Background: Since its discovery, severe fever with thrombocytopenia syndrome (SFTS) has been characterized by rapid progression and poor prognosis, and no specific treatment is available. The aim of this study was to investigate the early warning indicators of mortality in SFTS patients.

Methods: This is a retrospective cross-sectional study.