Ground settlement prediction for highway subgrades with sparse data using regression Kriging.

Ground settlement prediction for highway subgrades is crucial in related engineering projects. When predicting the ground settlement, sparse sample data are often encountered in practice, which greatly affects the prediction accuracy. However, this has been seldom explored in previous studies.

[A neonatal intelligent regulation system based on the combination of mild hypothermia mattress and hyperbaric oxygen chamber: introduction to a patent].

Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease that affects brain function in neonates. At present, mild hypothermia and hyperbaric oxygen therapy are the main methods for the treatment of neonatal HIE; however, they are independent of each other and cannot be combined for synchronous treatment, without monitoring of brain function-related physiological information. In addition, parameter setting of hyperbaric oxygen chamber and mild hypothermia mattress relies on the experience of the medical practitioner, and the parameters remain unchanged throughout the medical process.

Effect of Tanshinone IIA on Gut Microbiome in Diabetes-Induced Cognitive Impairment.

Diabetes-induced cognitive impairment (DCI) presents a major public health risk among the aging population. Previous clinical attempts on known therapeutic targets for DCI, such as depleted insulin secretion, insulin resistance, and hyperglycaemia have delivered poor patient outcomes. However, recent evidence has demonstrated that the gut microbiome plays an important role in DCI by modulating cognitive function through the gut-brain crosstalk.

Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling.

Objective: This study assessed the anti-arthritic effect and protection of Gedunin (GDN) on joint tissues and revealed the possible mechanism in suppressing rheumatoid arthritis (RA).

Methods: LPS-induced macrophages and TNF--stimulated synovial fibroblasts (MH7A) or IL-1-stimulated primary rheumatoid arthritis synovial fibroblasts (RASFs) were used to evaluate the antiinflammatory effect of GDN. In addition, CIA-induced arthritis was employed here to evaluate the anti-arthritic effect.

lncRNA028466 regulates Th1/Th2 cytokine expression and associates with Echinococcus granulosus antigen P29 immunity.

Background: Cystic echinococcosis (CE) is a parasitic disease that is caused by Echinococcus granulosus (Eg). The recombinant Echinococcus granulosus antigen P29 (rEg.P29) was shown to confer effective immunity to sheep and mice during E.

Effects of suppressing Smads expression on wound healing in Hyriopsis cumingii.

As a specific pearl mussel in China, Hyriopsis cumingii has enormous economic value. However, the organism damage caused by pearl insertion is immeasurable. TGF-β/Smad signal transduction pathways are involved in all phases of wound healing.

[Cloning, Expression and Immungenicity Analysis of Antigen Eg-01883 Screened from Protoscoleces of Echinococcus granulosus].

Objective: To screen for the Echinococcus granulosus 01883（Eg-01883） specifically expressed at the protoscolex period, clone and express this molecule as well as analyse its immunogenicity.

Methods: Eg-01883, which is highly expressed at the protoscolex period but not in oncosphere， was screened by analysing the published mRNA sequences of E. granuolosus.

[Position analysis of three recombinant proteins of Echinococcus granulosus protoscolex with two-dimensional electrophoresis].

Objective: To obtain specific antibodies of the three recombinant antigens obtained previously, rEgZW-5, rEg14-3-3 and rEgP-29, for identifying the corresponding proteins in two-dimensional electrophoretogram of Echinococcus granulosus protoscolex.

Methods: The distribution of proteins from E. granulosus protoscoleces was judged by SDS-PAGE previously.

[Formation of pyrrole adducts in 2,5-hexanedione-containing human serum cultured in vitro].

Objective: To investigate the relationship between formation of pyrrole adducts and concentration of 2, 5-hexanedione (2, 5-HD) and to provide an experimental basis for the study on toxicity of n-hexane.

Methods: Serum samples were collected from normal persons and were then filtered and sterilized. They were mixed with 2,5-HD to obtain sera with final 2, 5-HD concentrations of 10, 25, 50, 100, and 200 mg/L, and blank serum was also prepared.

[Advances in researches on application of Bayesian methods to QTL mapping].

In many cases, Bayesian methods can solve problems of interest more directly than a classical approach. Its utility lies on the incorporation of prior information. In recent years, with the development of high-speed computer and advances of MCMC algorithm, Bayesian methods have been employed in many genetic areas, such as population genetics, molecular evolution, linkage mapping, and quantitative genetics and so on.