Baicalein as a potent antifungal agent against : synergy with fluconazole and sustainable production through probiotic-mediated bioconversion.

Fungal infections, particularly those caused by , represent a significant global health concern, with drug resistance and biofilm formation posing considerable challenges to effective treatment. Baicalein, a flavonoid derived from baicalin found in , has demonstrated considerable antifungal efficacy. Moreover, the combination of baicalein and fluconazole demonstrated a notable synergistic effect.

Thrombus rooting in the pulmonary arteriovenous fistula in a patient with cryptogenic stroke, a case report.

Background: Cryptogenic stroke constitutes approximately 40% of ischemic strokes in young adults, imposing a significant socioeconomic burden. However, the source of embolus has been specifically investigated in a few number of studies. In this report, We document the first case of a cryptogenic stroke associated with a pulmonary arteriovenous fistula (PAVF), providing evidence of mural thrombus formation within the PAVF vessel.

Is the recurrence rate higher in obese patients undergoing inguinal hernia surgery?

Purpose: This study aimed to evaluate whether obese patients undergoing inguinal hernia repair surgery have a higher recurrence rate and compare the clinical outcomes of obese and non-obese patients.

Materials And Methods: The databases of PubMed, EMBASE, and Cochrane Library were used to search for eligible studies from inception to November 1, 2024. Mean difference (MD), Odds ratios (OR) and 95% confidence intervals (Cl) were pooled up to analyze.

ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.

Anillin (ANLN) is a highly conserved protein involved in cytokinesis and cytoskeletal remodeling. This study investigates the role of ANLN in head and neck squamous cell carcinoma (HNSCC) progression and its impact on the tumor immune microenvironment, with a focus on the combination of ANLN silencing and anti-programmed cell death protein 1 (PD-1) therapy. Through and experiments, along with clinical specimen analysis, we discovered that silencing ANLN not only inhibits the malignant progression of HNSCC but also reduces the activation of the extracellular signal-regulated kinase-mitogen-activated protein kinase (ERK-MAPK) signaling pathway and decreases programmed death ligand-1 (PD-L1) expression.

CTSL Promotes Autophagy in Laryngeal Cancer Through the IL6-JAK-STAT3 Signalling Pathway.

Cathepsin L (CTSL) is an important oncogene. However, its mechanism of action in laryngeal cancer is still unclear. This study aims to explore the role of CTSL in laryngeal cancer and its clinical significance.

Downregulation of HDAC2 attenuates ventricular arrhythmias in a mouse model of cardiac hypertrophy through upregulation of KCHIP2 expression.

Aims: Decrease in repolarizing K+ currents, particularly the fast component of transient outward K+ current (Ito,f), prolongs action potential duration (APD) and predisposes the heart to ventricular arrhythmia during cardiac hypertrophy. Histone deacetylases (HDACs) have been suggested to participate in the development of cardiac hypertrophy, and class I HDAC inhibition has been found to attenuate pathological remodeling. This study investigated the potential therapeutic effects of HDAC2 on ventricular arrhythmia in pressure overload-induced cardiac hypertrophy.

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study.

Objective: This study was to employ 18F-flurodeoxyglucose (FDG-PET) to evaluate the resting-state brain glucose metabolism in a sample of 46 patients diagnosed with disorders of consciousness (DoC). The aim was to identify objective quantitative metabolic indicators and predictors that could potentially indicate the level of awareness in these patients.

Methods: A cohort of 46 patients underwent Coma Recovery Scale-Revised (CRS-R) assessments in order to distinguish between the minimally conscious state (MCS) and the unresponsive wakefulness syndrome (UWS).

The role of lymph node level ratio in predicting prognosis and the benefits of postoperative radiotherapy in patients with pathological N1 stage head and neck squamous cell carcinoma.

Objective: To analyze the role of lymph node level ratio (LNLR) in predicting prognosis and the benefits of postoperative radiotherapy (PORT) in patients with pathological N1 (pN1) head and neck squamous cell carcinoma (HNSCC).

Methods: Patients with pN1 HNSCC from January 2011 to February 2021 were included. Patients were grouped by the LNLR, lymph node yield (LNY), and lymph node ratio (LNR) and were analyzed with the Kaplan-Meier method and multivariate Cox model.

Interfacial Engineering with a Conjugated Conductive Polymer for a Highly Reversible Zn Anode.

For Zn metal batteries, the Zn anode faces several challenges, including Zn dendrites, hydrogen evolution, and corrosion. These issues are closely related to the Zn deposition process at the electrode/electrolyte interface. Herein, we propose interfacial engineering to protect the Zn anode and induce homogeneous deposition using conjugated cyclized polyacrylonitrile (cPAN) polymer nanofibers.

Polyhydroxy starch with abundant hydroxyls and a unique structure enables uniform Zn deposition.

Zinc metal is a promising anode material for zinc-ion batteries (ZIBs), but severe side reactions and dendrite formation hinder its commercialization. In this study, starch is introduced into the ZnSO electrolyte for stabilizing the Zn anode. With abundant hydroxyl groups, starch can reconstruct the H-bond system in the electrolyte, suppressing side reactions.

Radiation Therapy Improves Survival in Patients with Distant Metastatic Head and Neck Squamous Cell Carcinoma: A Retrospective Study.

Background: The role of radiation therapy in patients with distant metastatic squamous cell carcinoma of the head and neck (mHNSCC) is unclear. In this study, we compare the differences in survival among mHNSCC patients treated with chemotherapy plus radiotherapy (RT) vs. chemotherapy alone.

The Words Children Hear and See: Lexical Diversity Across-Modalities and Its Impact on Lexical Development.

Early vocabulary development benefits from diverse lexical exposures within children's language environment. However, the influence of lexical diversity on children as they enter middle childhood and are exposed to multimodal language inputs remains unclear. This study evaluates global and local aspects of lexical diversity in three 1.

High-rate nitrogen and phosphorus removal in a sulfur and pyrrhotite modified foam concrete constructed wetland.

In order to develop constructed wetland (CW) with high-rate N and P removal, sulfur and pyrrhotite modified foam concrete (SPFC) was prepared and used as a substrate to construct CW (SPFC-CW). At hydraulic retention time 6 h, SPFC-CW achieved effluent total nitrogen (TN) 9.96 mg/L and PO-P 0.

Foam FeSO modified limestone sulfur concrete for non-stink and high-rate nitrogen and phosphorus removal from wastewater.

Aiming at disadvantages of conventional sulfur-limestone autotrophic denitrification system, such as producing stink (HS) and low-rate nitrogen and phosphorus removal from wastewater with low C/N, foam FeSO modified limestone sulfur concrete (FFLSC) was prepared. Experimental parameters of FFLSC biofilter, such as hydraulic retention time (HRT), influent NO-N, additional alkalinity and COD addition, were tested. For wastewater without COD, FFLSC biofilter could simultaneously remove TON (NO-N+NO-N) from 22.

Electric field-induced alignment of Ag/Au nanowires for ultrasensitive in situ detection of Interleukin-6.

Interleukin-6 (IL-6) is a key parameter and critical role in cancer progression. However, for detection of IL-6 in colorectal cancer diagnosis, developing a sensitive biosensor is necessary and very important. In this paper, to enhance the sensitivity of IL-6 electrochemical biosensor, the electric field was used to orient arrangement of silver nanowires (AgNWs) to be free-standing AgNWs electrode.

Intestine epithelial-specific hypoxia-inducible factor-1α overexpression ameliorates western diet-induced MASLD.

Background: Intestine epithelial hypoxia-inducible factor-1α (HIF-1α) plays a critical role in maintaining gut barrier function. The aim of this study was to determine whether pharmacological or genetic activation of intestinal HIF-1α ameliorates western diet-induced metabolic dysfunction-associated steatotic liver disease.

Methods: Metabolic effects of pharmacological activation of HIF-1α by dimethyloxalylglycine were evaluated in HIF-α luciferase reporter (ODD-luc) mice.

A carrageenan-induced highly stable Zn anode by regulating interface chemistry.

Zinc-ion batteries (ZIBs) are promising on account of the inherent safety, minimal toxicity, cost-effectiveness, and high theoretical capacity. However, the critical issues including the Zn dendrites and side reactions impede their commercial application. Here, we propose green, non-toxic and biological carrageenan (Carr) serving as an electrolyte additive to address the aforementioned issues.

The Treatment of Primary Lymphoepithelioma-Like Carcinoma in the Head and Neck and Nasopharyngeal Carcinoma.

Background: An uncommon cancer, lymphoepithelioma-like carcinoma (LELC) resembles undifferentiated nasopharyngeal carcinoma (NPC) histologically. The aim is mainly to introduce the diagnosis and treatment of LELC and compare it with NPC in our descriptive study.

Methods: A total of 278 patients with NPC and 157 patients with head and neck LELC had their medical records examined in this study.

A universal method for seizure onset zone localization in focal epilepsy using standard deviation of spike amplitude.

Background: Precisely localizing the seizure onset zone (SOZ) is critical for focal epilepsy surgery. Existing methods mainly focus on high-frequency activities in stereo-electroencephalography, but often fail when seizures are not driven by high-frequency activities. Recognized as biomarkers of epileptic seizures, ictal spikes in SOZ induce epileptiform discharges in other brain regions.

Overcoming Debye screening effect in field-effect transistors for enhanced biomarker detection sensitivity.

Field-effect transistor (FET)-based biosensors not only enable label-free detection by measuring the intrinsic charges of biomolecules, but also offer advantages such as high sensitivity, rapid response, and ease of integration. This enables them to play a significant role in disease diagnosis, point-of-care detection, and drug screening, among other applications. However, when FET sensors detect biomolecules in physiological solutions (such as whole blood, serum, ), the charged molecules will be surrounded by oppositely charged ions in the solution.

The unique contribution of uncertainty reduction during naturalistic language comprehension.

Language comprehension is an incremental process with prediction. Delineating various mental states during such a process is critical to understanding the relationship between human cognition and the properties of language. Entropy reduction, which indicates the dynamic decrease of uncertainty as language input unfolds, has been recognized as effective in predicting neural responses during comprehension.

Architecting a transcriptional repressor-based genetic inverter for tryptophan derived pathway regulation in Escherichia coli.

Efficient microbial cell factories require intricate and precise metabolic regulations for optimized production, which can be significantly aided by implementing regulatory genetic circuits with versatile functions. However, constructing functionally diverse genetic circuits in host strains is challenging. Especially, functional diversification based on transcriptional repressors has been rarely explored due to the difficulty in inverting their repression properties.

MBV-Pipe: A One-Stop Toolbox for Assessing Mouse Brain Morphological Changes for Cross-Scale Studies.

Mouse models are crucial for neuroscience research, yet discrepancies arise between macro- and meso-scales due to sample preparation altering brain morphology. The absence of an accessible toolbox for magnetic resonance imaging (MRI) data processing presents a challenge for assessing morphological changes in the mouse brain. To address this, we developed the MBV-Pipe (Mouse Brain Volumetric Statistics-Pipeline) toolbox, integrating the methods of Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL)-Voxel-based morphometry (VBM) and Tract-Based Spatial Statistics (TBSS) to evaluate brain tissue volume and white matter integrity.

The Multifunctional Role of KCNE2: From Cardiac Arrhythmia to Multisystem Disorders.

The KCNE2 protein is encoded by the gene and is a member of the KCNE protein family, also known as the MinK-related protein 1 (MiRP1). It is mostly present in the epicardium of the heart and gastric mucosa, and it is also found in the thyroid, pancreatic islets, liver and lung, among other locations, to a lesser extent. It is involved in numerous physiological processes because of its ubiquitous expression and partnering promiscuity, including the modulation of voltage-dependent potassium and calcium channels involved in cardiac action potential repolarization, and regulation of secretory processes in multiple epithelia, such as gastric acid secretion, thyroid hormone synthesis, generation and secretion of cerebrospinal fluid.