Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from and their vasorelaxant activities.

Two new sesquiterpenoids, curcumanes E () and F (), were isolated from the rhizome of , and their structures and absolute configurations were examined using extensive spectroscopic analyses and ECD calculations. Interestingly, compounds and are diastereoisomers possessing a rare sesquiterpenoid skeleton that has been reported only once before. Both curcumanes E and F exhibit significant vasorelaxant effects against KCl-induced contraction of rat aortic rings, with EC values of 5.

Vasorelaxant effect of curcubisabolanin A isolated from Curcuma longa through the PI3K/Akt/eNOS signaling pathway.

Ethnopharmacological Relevance: Curcuma longa L. (Zingiberaceae) is a known blood-activating and stasis-removing traditional Chinese medicine and has relevant pharmacological properties. The rhizomes of C.

[Expression Analysis of miRNA Profiles in Apheresis Platelets during Storage].

Objective: To study the expression profiles changes of miRNA in apheresis platelets after 1, 3 and 5 days of storage.

Methods: The apheresis platelets were collected from 20 volunteer blood donors. After mixing fully, the platelets were stored in a shaker with (22±2) ℃ horizontal oscillation.

Seven pairs of new enantiomeric sesquiterpenoids from Curcuma phaeocaulis.

Seven pairs of new enantiomeric sesquiterpenoids, (+)/(-)-phaeocauline A - G [(+)/(-)-1-7], were isolated from the rhizomes of Curcuma phaeocaulis by chiral HPLC separation. Their structures, including absolute configurations, were determined by spectroscopic analyses and ECD data. The isolates were assessed for vasorelaxant, anti-platelet aggregative, and neuroprotective activities.

Curcumane C and (±)-curcumane D, an unusual seco-cadinane sesquiterpenoid and a pair of unusual nor-bisabolane enantiomers with significant vasorelaxant activity from Curcuma longa.

A new seco-cadinane sesquiterpenoid (curcumane C, 1) and a pair of new nor-bisabolene enantiomers [(+)- and (-)-curcumane D, 2a and 2b] were isolated from C. longa. Compound 1 possesses an unusual 4,5-seco-cadinane skeleton with a tetrahydrophthalide moiety, while 2a and 2b contain an unusual 15-nor-bisabolene skeleton with a chromone core.

Photoredox/Cobalt-Catalyzed Phosphinyloxy Radical Addition/Cyclization Cascade: Synthesis of Phosphaisocoumarins.

A novel visible-light photoredox-catalyzed phosphinyloxy radical addition/cyclization cascade of arylphosphinic acids or arylphosphonic acid monoesters with alkynes has been developed, which provides an efficient and practical access to various phosphaisocoumarins by using a dual catalytic system containing an acridinium photosensitizer and a cobaloxime proton-reducing catalyst [Co(dmgH)]PyCl at ambient temperature. This method has advantages of a broad substrate scope, mild condition, as well as no sacrificial oxidant.

Curcumanes A and B, Two Bicyclic Sesquiterpenoids with Significant Vasorelaxant Activity from Curcuma longa.

Two novel sesquiterpenoids, curcumanes A (1) and B (2), possessing unprecedented skeletons with a dicyclo[3.2.1]octane and a dicyclo[3.

Visible-Light-Driven Aza-ortho-quinone Methide Generation for the Synthesis of Indoles in a Multicomponent Reaction.

A visible-light-driven radical-mediated strategy for the in situ generation of aza-ortho-quinone methides from 2-vinyl-substituted anilines and alkyl radical precursors is described. This process enables an efficient multicomponent reaction of 2-vinylanilines, halides, and sulfur ylides, and has a wide substrate scope and good functional group tolerance. Treatment of the cycloaddition products with a base leads to densely functionalized indoles in a single-flask operation.

[Effects of shading in summer and autumn on physiological and biochemical characteristics of 'Huangjinya' in Shandong Province, China].

In order to ensure the suitable shade model for 'Huangjinya' tea plant in Shandong Province, black or blue shading net at 55%, 70% or 85% shading rates was selected to recover tea garden in summer and autumn, then micro-climate of tea garden, leaf color, chlorophyll fluorescence parameters, growth status and biochemical composition of tea shoots were investigated.The results showed that compared with the control, light intensity and air temperature in tea garden, leaf temperature of tea plants in different shading treatments significantly decreased, while air humidity in tea garden increased. The contents of chlorophyll in the tea leaves were obviously increased with increasing the shading rate, which resulted in the leaf color becoming green.

Effects of epidermal growth factor on the growth of human gastric cancer cell and the implanted tumor of nude mice.

Aim: Epidermal growth factor (EGF) plays an important role in the regulation of gastrointestinal tissue growth and development, and it can stimulate epithelial proliferation, cell differentiation and growth. It has been established that the EGF can promote gastric cytoprotection and ulcer healing. But the potential ability of EGF to regulate the gastric cancer growth is unknown.