Stabilizing Precursor Solutions by Proton-Rich Additive for High-Performance Air-Processed Solar Cells.

Storing perovskite precursor solutions under ambient conditions poses a significant challenge to commercialization, as humidity and oxidation accelerate ageing and introduce defects in devices. A major contributor to solution ageing and impurity perovskite phases is the deprotonation of hybrid organic cations, specifically methylammonium (MA) and formamidinium (FA). In this work, a proton-rich additive, 4-(aminomethyl)pyridine 2-iodide, is used to inhibit MA deprotonation in precursor solutions by generating free H, thereby mitigating the degradation of organic cations under oxygen and humidity stress.

Hyperpolarized Xe diffusion-weighted MRI of the lung with 3D golden-angle radial sampling and keyhole reconstruction.

Background: Hyperpolarized (HP) Xe multiple b-values diffusion-weighted imaging (DWI) facilitates the assessment of pulmonary morphology. However, conventional DWI method, such as 2D GRE DWI, is limited in its application due to the long acquisition time and relatively thick slice.

Purpose: To develop a method combining 3D golden-angle radial sampling with keyhole reconstruction (GRSK) for accelerating Xe multiple b-values DWI and obtaining thinner slice.

A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report.

Anaplastic thyroid carcinoma (ATC) is a rare and highly aggressive malignancy characterized by a poor prognosis, with a median survival time of approximately 3 to 4 months. In this report, we present a case involving a 59-year-old patient diagnosed with ATC, who experienced swift local recurrence and pulmonary metastasis following radical thyroidectomy. Comprehensive Sanger sequencing of the resected tumor tissue revealed no mutations in the TERT promoter or the BRAF V600E gene.

Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling.

As a gatekeeper of the airway epithelial cells, E-cadherin is not only a critical component for the maintenance of epithelial integrity, but also engaged in pathological processes through the release of a soluble form (sE-cadherin). This study was aimed to investigate the role of sE-cadherin in ALI/ARDS. Serum samples from patients with ARDS and healthy volunteers were collected for the detection of sE-cadherin.

Flavonoids serve as a promising therapeutic agent for ischemic stroke.

Ischemic stroke (IS) continues to be a major public health concern and is characterized by significantly high mortality and disabling rates. Inhibiting nerve cells death and enhancing the repair of ischemic tissue are important treatment concepts for IS. Currently, the mainstream treatment strategies mainly focus on short-term care, which underscores the urgent need for novel therapeutic strategies for long-term care.

The C3H gene PtZFP2-like in Pinellia ternata acts as a positive regulator of the resistance to soft rot caused by Pectobacterium carotovorum.

Pinellia ternata (Thunb.) Breit is a member of the Araceae family and is globally distributed. The dry tuber has been used as a traditional Chinese medicine for over 2,000 years.

The Disruptions of Sphingolipid and Sterol Metabolism in the Short Fiber of Mutant Revealed Obesity Impeded Cotton Fiber Elongation and Secondary Cell Wall Deposition.

Boosting evidence indicated lipids play important roles in plants. To explore lipid function in cotton fiber development, the lipid composition and content were detected by untargeted and targeted lipidomics. Compared with rapid elongation fibers, the lipid intensity of 16 sub-classes and 56 molecular species decreased, while only 7 sub-classes and 26 molecular species increased in the fibers at the stage of secondary cell wall deposition.

Three-Dimensional Images for Thoracoscopic Segmentectomy: An Alternative to Preoperative Localization.

Introduction: This study aimed to compare the outcomes of three-dimensional (3D) image-guided video-assisted thoracic surgery (VATS) segmentectomy performed with and without preoperative localization for the resection of small pulmonary nodules.

Method: Between July 2015 and December 2022, 439 patients who underwent 3D image-guided VATS segmentectomy for early-stage lung cancer were enrolled. Based on whether preoperative localization was performed, the patients were divided into two groups as follows: the localization (n = 96) and nonlocalization groups (n = 343).

Long Non-Coding RNAs: Key Regulators of Tumor Epithelial/Mesenchymal Plasticity and Cancer Stemness.

Long non-coding RNAs (lncRNAs) are a class of non-coding RNA molecules with transcripts longer than 200 bp, which were initially thought to be noise from genomic transcription without biological function. However, since the discovery of H19 in 1980 and Xist in 1990, increasing evidence has shown that lncRNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels through specific regulatory actions and are involved in the development of cancer and other diseases. Despite many lncRNAs being expressed at lower levels than those of protein-coding genes with less sequence conservation across species, lncRNAs have become an intense area of RNA research.

Abundant geographical divergence of Clostridioides difficile infection in China: a prospective multicenter cross-sectional study.

Clostridioides difficile is the predominant pathogen in hospital-acquired infections and antibiotic-associated diarrhea. Dedicated networks and annual reports for C. difficile surveillance have been established in Europe and North America, however the extensive investigation on the prevalence of C.

Effects of higher-order interactions on the evolution of cooperative behavior in hyperbolic scale-free network.

This study proposes an innovative hypergraph model to explore the effects of higher-order interactions on the evolution of cooperative behavior in a hyperbolic scale-free network. By adjusting the heterogeneity coefficient and clustering coefficient of the hyperbolic scale-free network, four distinct network structures with notable differences can be obtained. We then map pairwise and three-way interactions to 2-hyperedges and 3-hyperedges, constructing a hypergraph model with higher-order interactions.

Biosynthesis of bromoform by fungi provides a natural pathway to mitigate enteric methane emissions from ruminants.

The ruminant livestock industry is the largest agricultural emissions source of anthropogenic greenhouse gases, primarily from enteric methane. Several technologies, both natural and synthetic are being investigated to mitigate enteric methane emissions. Macroalgae derived feed ingredients that contain bromoform, a recognised inhibitor of methanogenesis, are an effective natural approach for methane mitigation.

Photothermal-Driven α-Amylase-Modified Polydopamine Pot-Like Nanomotors for Enhancing Penetration and Elimination of Drug-Resistant Biofilms.

Biological enzyme-functionalized antibacterial nanoparticles, which can degrade biofilm and kill bacteria under mild reaction conditions, have attracted much attention for the elimination of deep-seated bacterial infections. However, the poor diffusion and penetration capabilities of recently developed biological enzyme-functionalized antibacterial nanoparticles in biofilm severely impair the eradication efficacy of deep-seated bacteria. Herein, a photothermal-driven nanomotor (denoted as APPNM) is developed for enhancing the elimination of drug-resistant biofilms and the eradication of deep-seated bacteria.

273.6 Tbit/s real-time S + C + L-band same-wavelength bidirectional wavelength division multiplexing transmission in anti-resonant hollow-core fiber.

Based on its ultra-low backscattering characteristic, anti-resonant hollow-core fiber is a good medium for bidirectional transmission, which means that the wavelengths of the transmission channels are the same in both directions. In this Letter, we present the first, to the best of our knowledge, demonstration of S + C + L-band same-wavelength bidirectional transmission in an anti-resonant hollow-core fiber. By using a commercial real-time coherent optical transceivers and amplified spontaneous emission (ASE) source, a total net throughput of 273.

Genetically-encoded targeted protein degradation technology to remove endogenous condensation-prone proteins and improve crop performance.

Effective modulation of gene expression in plants is achievable through tools like CRISPR and RNA interference, yet methods for directly modifying endogenous proteins remain lacking. Here, we identify the E3 ubiquitin ligase E3TCD1 and develope a Targeted Condensation-prone-protein Degradation (TCD) strategy. The X-E3TCD1 fusion protein acts as a genetically engineered degrader, selectively targeting endogenous proteins prone to condensation.

Individual color matches and cone spectral sensitivities in 100 observers of varying age.

Previously we reported color matches measured in young adults using a newly developed multi-wavelength LED-based visual trichromator with which we estimated their individual L-, M- and S-cone spectral sensitivities. Here, we extend those measurements to include 70 additional observers aged between 8 to 80 years. As in our previous work, a series of color matching measurements were made to a reference white.

Relationship between intraoperative blood pressure variability and postoperative acute kidney injury in pediatric cardiac surgery.

Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a notably common complication in pediatrics, with an incidence rate ranging from 15 to 64%. This rate is significantly higher than that observed in adults. Currently, there is a lack of substantial evidence regarding the association between intraoperative blood pressure variability (BPV) during cardiac surgery with cardiopulmonary bypass (CPB) and the development of AKI in pediatric patients.

Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis.

Richter syndrome (RS), characterized by aggressive lymphoma arising from chronic lymphocytic leukaemia (CLL), presents a poor response to treatment and grim prognosis. To elucidate RS mechanisms, paired samples from a patient with DLBCL-RS were subjected to single-cell RNA sequencing (scRNA-seq) and high-throughput chromosome conformation capture (Hi-C) sequencing. Over 10,000 cells were profiled via scRNA-seq, revealing the comprehensive B cell transformation in RS.

[Homer 1a overexpression alleviates nerve injury in mice with traumatic brain injury by regulating autophagy mediated by PI3K/AKT/mTOR pathway].

Objective To investigate the effects and molecular mechanism of Homer protein homolog 1a (Homer 1a) overexpression on nerve injury in mice with traumatic brain injury (TBI). Methods Sixty male C57BL/6 mice were randomly divided into five groups: sham group, TBI group, empty lentivirus (Lv-NC) group, Homer 1a overexpression lentivirus (Lv-Homer 1a) group and Lv-Homer 1a + 740 Y-P group, with 12 mice in each group. The lentivirus was orthotopic injected into the cerebral cortex of mice 5 d before modeling, while 740 Y-P was injected intraperitoneally 1 d before modeling.

SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis.

Background: Oncolytic viruses (OVs) are increasingly recognized as promising tools for cancer therapy, as they selectively infect and destroy tumor cells while leaving healthy cells unharmed. Despite considerable progress, the limited therapeutic efficacy of OV-based virotherapy continues to be a significant challenge in cancer treatment.

Methods: The SMAC/DIABLO gene was inserted into the genome of vesicular stomatitis virus (VSV) to generate VSV-S.

Combination of plasma acoustic emission signal and laser-induced breakdown spectroscopy for accurate classification of steel.

Background: Fast and accurate classification of steel can effectively improve industrial production efficiency. In recent years, the use of laser-induced breakdown spectroscopy (LIBS) in conjunction with other techniques for material classification has been developing. Plasma Acoustic Emission Signal (PAES) is a type of modal information separate from spectra that is detected using LIBS, and it can reflect some of the sample's physicochemical information.

rs11614913 C Allele is Associated with Increased Wilms Tumor Susceptibility in Chinese Children.

Wilms tumor, also known as nephroblastoma, is the most common kidney cancer in children. The rs11614913 T>C polymorphism has been identified as a susceptibility locus in various adult cancers. However, it is unclear whether this polymorphism also increases the risk of pediatric cancer.

, a R2R3-MYB transcription factor from purple tea (), positively regulates anthocyanin biosynthesis.

In tea (), anthocyanins are important secondary metabolites that are linked to leaf color. Anthocyanin biosynthesis is a complex biological process, in which multiple genes including structural and regulatory genes are involved. Here, we describe the cloning and characterizing of a new R2R3-MYB transcription factor gene, , isolated from purple tea variety ''.

Talaromyces marneffei central nervous system infection unveiled by the novel Mp1p antigen detection assay in AIDS patient.

Background: In acquired immunodeficiency syndrome patients, Talaromyces marneffei infections are mostly disseminated and may involve the skin, mucosa, respiratory system, digestive system, lymphatic system, and as some reports indicate, the nervous system. Mp1p, a cell wall-specific polysaccharide in Talaromyces marneffei, is used for laboratory diagnosis of Talaromyces marneffei in blood and urine samples. However, Cerebrospinal fluid Mp1p diagnosis of Talaromyces marneffei central nervous system infection has not been reported.