Publications by authors named "Ming Li"

Understanding the insecticide resistance mechanisms and their underlying regulatory pathways is essential for pest management. Previous findings indicated that the overexpression of P450 gene, CYP6ER1, was a key mechanism for sulfoxaflor metabolic resistance in Nilaparvata lugens. However, it remains unclear whether quantitative changes in the target nicotinic acetylcholine receptors (nAChRs) contribute to sulfoxaflor resistance and the underlying regulatory mechanisms involved.

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  • Jumbo phages are large viruses with genomes over 200 kbp, and little is known about their life cycle and unique reproductive genes.
  • Researchers assembled 668 high-quality jumbo phage genomes from 955 samples of various animal species and identified the largest known phage genome at 716 kbp, revealing they can synthesize NAD and contain numerous NAD-consuming enzymes.
  • The study highlights the widespread presence of NAD-jumbo phages in different ecosystems, emphasizing the need for further research on their ecological roles and survival strategies.
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The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis of valuable molecules. We report herein an electrochemical desaturation and β-thiocyanation of cyclic amides under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions and can be applied for late-stage functionalization of bioactive molecules.

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Background: The assessment of lung adenocarcinoma significantly depends on the proportion of solid components in lung nodules. Traditional one-dimensional consolidation tumor ratio (1D CTR) based on ideal, uniformly dense solid components lacks precision. There is no consensus on the CT threshold for evaluating invasiveness using the threshold segmentation method.

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Background: HBeAg-positive chronic hepatitis B (CHB) with low HBsAg levels represents a relatively rare serological pattern and is closely associated with the severity of liver disease. However, the underlying mechanisms in such cases remain largely unclear.

Methods: Treatment-naïve HBeAg-positive CHB patients with low HBsAg levels in China were enrolled and analysed.

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The giant grouper (Epinephelus lanceolatus) is a large coral reef fish distributed in the Indian Ocean and the Pacific Ocean. With a high market value, this species can grow up to approximately 2.7 meters in length and weigh 440 kilograms.

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Objective: There has been no explanation for the exact mechanism of circRNAs in nasopharyngeal carcinoma (NPC). Circ_0007439 was investigated in this study to determine its role and mechanism in NPC.

Methods: To identify circ_0007439, microRNA (miR)-556-5p, and PTEN mRNA in NPC tissues and cells, RT-qPCR was employed.

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Purpose: To predict the serosal invasion of gastric cancer (GC) using dual-energy CT (DECT)-based parameters and analyze the diagnostic performance according to different subtypes.

Methods: The patients were divided into the T1-3 group and T4a group. The irregular region of interest (ROI) was manually delineated on the largest cross-section of the lesion.

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Gut mycobiota are part of the gut microbiome, typically derived from the host diet and living environment. In this study, we examined the gut mycobiota of three snub-nosed monkeys: Rhinopithecus roxellana, R. bieti, and R.

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Introduction: Immunotherapy, especially immune checkpoint blockade (ICB), holds promise as a therapeutic strategy in colorectal cancer (CRC) by harnessing the patient's immune system to target malignant cells. Particularly, the PD-1/PD-L1 axis is widely recognized for its critical role in tumor microenvironment immunosuppression. Antibodies targeting PD-1 or PD-L1 have shown sustained efficacy against various cancers, including CRC.

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  • * A control algorithm utilizing neural networks was created to optimize the climbing process, and an experiment was conducted to test the robot with volunteers.
  • * The results indicated that the exoskeleton reduced muscle strain (measured through sEMG signals) in key muscles, confirming its effectiveness in aiding personnel during tower climbing tasks.
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With the rapid development of hydrogen pipelines, their safety issues have become increasingly prominent. In order to evaluate the properties of pipeline materials under a high-pressure hydrogen environment, this study investigates the hydrogen embrittlement sensitivity of X70 welded pipe in a 10 MPa high-pressure hydrogen environment, using slow strain rate testing (SSRT) and low-cycle fatigue (LCF) analysis. The microstructure, slow tensile and fatigue fracture morphology of base metal (BM) and weld metal (WM) were characterized and analyzed by means of ultra-depth microscope, scanning electron microscope (SEM), electron backscattering diffraction (EBSD), and transmission electron microscope (TEM).

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DHA and EPA, as indispensable n-3 highly unsaturated fatty acids (HUFAs), exert a fundamental influence on regulating fish growth, lipid metabolism, and overall well-being. However, there is a notable lack of data concerning their effects on the F female generation of Yangtze sturgeon. Over a ten-month period, this study assessed the impacts of various dietary concentrations of n-3 HUFAs (0.

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Smartphones contain powerful and enabling technology components that can be re-applied toward procedural tasks commonly used in everyday clinical image-guided therapies and minimally invasive procedures that use three-dimensional information and feedback during procedures. Smartphone applications are a relatively young field of research that have potential in interventional radiology (IR) toward improvement of accuracy and standardization for needle-based procedures like biopsy and ablation. This review explores the adaptation of smartphones' built-in sensors for virtual and augmented reality uses in IR.

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Purpose: The stromal cell protein metalloproteinase 9 (MMP9), associated with extracellular matrix degradation and remodeling, promotes tumor invasion and metastasis and regulates cell adhesion molecule and cytokine activity. This study evaluated MMP9 in pan-cancer and screened for compounds and drug candidates that can inhibit it.

Methods: MMP9 expression in pan-cancer tissues was evaluated in a pan-cancer dataset from the University of California Santa Cruz database, along with the correlation between MMP9 and the tumor microenvironment (TME), RNA modification genes, and tumor mutation burden.

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Lactate, which was traditionally viewed as a metabolic byproduct of anaerobic glycolysis, has emerged as a significant signaling molecule involved in the development of tumors. Current studies highlight its dual function, where it not only fuels tumor development but also modulates immune responses. Lactate has an effect on various tumor-associated immune cells, promoting immunosuppressive conditions that facilitate tumor growth and immune evasion.

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In vertebrates, newly synthesized lysosomal enzymes traffick to lysosomes through the mannose-6-phosphate (M6P) pathway. The Golgi membrane protein TMEM251 was recently discovered to regulate lysosome biogenesis by controlling the level of GlcNAc-1-phosphotransferase (GNPT). However, its precise function remained unclear.

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Cancer treatment faces significant challenges including inadequate tumor specificity, drug resistance, and severe side effects, often resulting in unsatisfactory patient outcomes. Nanomedicines offer a transformative platform for tumor-targeted drug delivery and antitumor potency activation, providing an indispensable strategy for overcoming the severe damage to normal tissues caused by the inherent "always-on" cytotoxicity of conventional therapeutic agents. This review focuses on the emerging concept of "nanoparticle-enabled in situ drug potency activation", where inactive or minimally toxic agents are selectively activated within tumors to enhance the therapeutic efficacy and minimize the adverse effects.

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We propose and experimentally demonstrate a novel protocol for transferring quantum states between superconducting cavities. This approach utilizes continuous two-mode squeezing interactions to generate entanglement without the exchange of any carrier photons. In contrast to the discrete operations of entanglement and Bell-state measurement in quantum teleportation, our scheme is symmetric and continuous.

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Keloid scarring is a fibroproliferative disease of the skin, which can significantly impact one's quality of life through cosmetic concerns, physical discomfort (itchy; painful), restricted movement, and psychological distress. Owing to the poorly understood pathogenesis of keloids and their high recurrence rate, the efficacy of keloid treatment remains unsatisfactory, particularly in patients susceptible to multiple keloids. We conducted fecal metagenomic analyzes and both untargeted and targeted plasma metabolomics in patients with multiple keloids (MK,  = 56) and controls with normal scars (NS,  = 60); tissue-untargeted metabolomics (MK,  = 35; NS,  = 32), tissue-targeted metabolomics (MK,  = 41; NS,  = 36), and single-cell sequencing analyzes (GSE163973).

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Humans no doubt use language to communicate about their emotional experiences, but does language in turn help humans understand emotions, or is language just a vehicle of communication? This study used a form of artificial intelligence (AI) known as large language models (LLMs) to assess whether language-based representations of emotion causally contribute to the AI's ability to generate inferences about the emotional meaning of novel situations. Fourteen attributes of human emotion concept representation were found to be represented by the LLM's distinct artificial neuron populations. By manipulating these attribute-related neurons, we in turn demonstrated the role of emotion concept knowledge in generative emotion inference.

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Background: Abdominal aortic calcification (AAC) serves as a reliable predictor of future cardiovascular incidents. This study investigated the association between dietary niacin intake and AAC in US adults.

Methods: In this study, we conducted a cross-sectional study of 2,238 individuals aged 40 years and older using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014.

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Article Synopsis
  • The study focuses on how allele dosage affects variations in traits of hexaploid sweet potato, based on deep sequencing of 294 accessions, creating a genome-wide variation map.* -
  • Genome-wide association studies revealed quantitative trait loci that link allele dosage to 23 agronomic traits, highlighting how sweet potato breeding has selectively increased these alleles to improve crop performance.* -
  • The research uncovers the evolutionary trend in the Mesoamerican gene pool towards higher dosage of beneficial alleles, with evidence from transgenic validation and identification of sequence variations influencing traits like tuber weight and flesh color.*
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Neuromodulation techniques effectively intervene in cognitive function, holding considerable scientific and practical value in fields such as aerospace, medicine, life sciences, and brain research. These techniques utilize electrical stimulation to directly or indirectly target specific brain regions, modulating neural activity and influencing broader brain networks, thereby regulating cognitive function. Regulating cognitive function involves an understanding of aspects such as perception, learning and memory, attention, spatial cognition, and physical function.

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