Computer simulation of progressive retinal nerve fiber layer loss in glaucoma: performance of event and trend analyses.

Purpose: Although event analysis (EA) and trend analysis (TA) have been widely adopted to evaluate glaucoma progression in clinical trials, there is poor agreement between the strategies and no consensus on strategy selection in clinical practice. With computer simulation of progressive loss of the retinal nerve fiber layer (RNFL), the authors compared the performance of TA and EA for the detection of glaucoma progression.

Methods: RNFL progression was modeled with reference to the individual's test-retest variability and the pattern and rate of progression.