Funmap: integrating high-dimensional functional annotations to improve fine-mapping.

Motivation: Fine-mapping aims to prioritize causal variants underlying complex traits by accounting for the linkage disequilibrium of GWAS risk locus. The expanding resources of functional annotations serve as auxiliary evidence to improve the power of fine-mapping. However, existing fine-mapping methods tend to generate many false positive results when integrating a large number of annotations.

A Preliminary Qualitative Exploration of the Lived Experiences of Presenteeism Among Taiwanese Nursing Staff.

Objective: The aim of this study was to explore the lived experiences of presenteeism among Taiwanese nursing staffs.

Background: Presenteeism is a subjective and multifaceted experience, but nurses have rarely been invited to provide their own views of presenteeism.

Methods: A qualitative study based on content analysis was conducted.

Effect of Boiling Treatment on Linoleic Acid-Induced Oxidation of Myofibrillar Protein in Grass Carp.

The aim of this study was to investigate the promotion of linoleic acid (OLA)-induced myofibrillar protein (MP) oxidation by boiling treatment. The effect of the boiling treatment on grass carp MP oxidation induced by OLA was investigated. The total sulfhydryl content, fluorescence intensity, and amino acid content were reduced with the increasing OLA concentration after the boiling treatment, while the boiled oxidized MP's carbonyl content (4.

An Emerging Toolkit of Ho Sensitized Lanthanide Nanocrystals with NIR-II Excitation and Emission for Bioimaging.

Optical imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for biomedical detection due to reduced tissue scattering and autofluorescence. However, the rational design of NIR-II probes with superior excitation wavelengths to balance the effects of tissue scattering and water absorption remains a great challenge. To address this issue, here we developed a series of Ho-sensitized lanthanide (Ln) nanocrystals (NaYF: Ho, Ln@NaYF) excited at 1143 nm, featuring tunable emissions ranging from 1000 to 2200 nm for bioimaging.

Stable Pickering emulsions of cinnamaldehyde were formulated using tannic acid-assisted cellulose nanofibers and applied for mango preservation.

Recent explorations into cinnamaldehyde (CIN) have identified its potential as a natural preservative, particularly when incorporated into active packaging to enhance the shelf-life of fruits and vegetables. This study explores the use of cellulose nanofiber (CNF)-stabilized Pickering emulsions as a novel delivery system for essential oils, demonstrating broad applicability in food preservation strategies. We employ CNF as Pickering stabilizers to effectively emulsify and encapsulate CIN, investigating the influence of tannic acid (TA) concentrations on the stability of these emulsions.

RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.

Osteoarthritis (OA) is a common age-related disease that is correlated with a high number of senescent chondrocytes in joint tissues. Heterogeneous nuclear ribonucleoprotein D (HNRNPD) is an RNA-binding protein whose expression imbalance is associated with cell senescence, but the role of HNRNPD in the occurrence and development of OA has not been reported. In this study, HNRNPD was found to be associated with the chondrocyte senescence process.

Pediatric urology patient transition to adulthood: Brief report on the barriers and shortcomings in a resource poor state.

Introduction And Objectives: To evaluate the readiness of pediatric spina bifida (SB) patients to transition from pediatric to adult urologic care. Since 1975 the survival rate of SB has increased from less than 50 % to 85 %. Adult SB patients have increased urologic needs due to their increased risk of complications including: 7-11 times risk of renal failure, 2 times risk of bladder cancer, and 46 times risk likely of UTIs.

Filtering-free complex-valued DSB-16QAM generation for a 100 G direct detection optical interconnection.

In this Letter, a complex-valued double-sideband 16QAM (CV-DSB-16QAM) signaling scheme is proposed and experimentally demonstrated in a 100-Gb/s intensity modulation/direct detection (IM/DD) interconnection system. Unlike the conventional real-valued double-sideband (DSB) quadrature amplitude modulation (QAM) of relatively lower spectral efficiency (SE) and single-sideband (SSB) QAM relying on sharp-edged optical filtering, the CV-DSB-16QAM signal is generated by combining two independent sideband modulated QPSK signals using a single intensity modulator with an optical filtering-free profile, which also saves one photodiode and one analog-to-digital-converter compared with the twin-SSB scheme. Compared to typical pulse amplitude modulation or SSB schemes, the proposed approach offers a compelling alternative for complex-valued DD systems' evolution, particularly in scenarios with high SE demands and controllable chromatic dispersion.

Photocatalytic material-microorganism hybrid systems in water decontamination.

Biological processes are widely used technologies for water decontamination, but they are often limited by insufficient bioavailable carbon sources or biorecalcitrant contaminants. The recently developed photocatalytic material-microorganism hybrid (PMH) system combines the light-harvesting capacities of photocatalytic materials with specific enzymatic activities of whole cells, efficiently achieving solar-to-chemical conversion. By integrating the benefits of both photocatalysis and biological processes, the PMH system shows great potential for water decontamination.

Association between dyslipidemia and depression: a cross-sectional analysis of NHANES data from 2007 to 2018.

Background: The relationship between depression and dyslipidemia remains controversial, with inconsistent findings across studies. This study aimed to investigate the association between blood lipid levels and depression using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018.

Methods: This cross-sectional study included 12,819 adult participants from NHANES.

Lily (Lilium spp.) LhERF061 suppresses anthocyanin biosynthesis by inhibiting LhMYBSPLATTER and LhDFR expression and interacting with LhMYBSPLATTER.

Ethylene has an essential function in the biosynthesis of anthocyanin. However, the molecular mechanism through which ethylene impacts the color of lily flower remains little appreciated. This study identified LhERF061, a dehydration-responsive element-binding (DREB family) transcription factor that suppresses anthocyanin biosynthesis in response to ethylene in lilies.

End-to-end learning strategy with channel-aided polar autoencoder in IM/DD optical interconnection.

An end-to-end (E2E) learning strategy with a channel-aided polar autoencoder (AE) is proposed and experimentally demonstrated in an intensity-modulation direct-detection optical interconnection system. With the global training of the E2E deep neural network, the learned fiber channel and transceiver characteristics are used to back-forward aid the channel indexes of AE, thus obtaining optimal polarization weight in polar encoding to mitigate signal impairments. The experimental results reveal that when the 50 GBaud PAM4 signals are transmitted over standard single mode fiber, the proposed polar AE by E2E learning strategy can effectively improve the received power sensitivity by 1.

Jointly polar-coded probabilistic shaping scheme based on many-to-one mapping in IM/DD optical DMT interconnection.

A joint channel coding and probabilistic shaping (PS) scheme is proposed and experimentally demonstrated in an intensity modulation and direct-detection optical discrete multi-tone (DMT) interconnection. The PS-32 quadrature amplitude modulation (PS-32QAM) is probabilistically reshaped from a 6-bit/symbol 64QAM signal based on polar-coded many-to-one (MTO) mapping, enabling a Gaussian-like symbol probability distribution without shaping or forward error correction redundancy. A bit-interleaved polar-coded modulation iterative decoding system based on joint QAM demapping and polar decoding is employed to retrieve the multi-labeled PS symbols.

Carbon-silicon-switch effect in enantioselective construction of silicon-stereogenic center from silacyclohexadienones.

Carbon-silicon-switch strategy, replacing one specific carbon atom in organic molecules with a silicon, has garnered significant interest for developing new functional molecules. However, the influence of a reaction regarding its selectivity and reactivity by carbon-silicon-switch strategy has far less been investigated. Here we discover an unusual carbon-silicon-switch effect in the enantioselective construction of silicon-stereogenic center.

Comprehensive Analysis and Verification of the Prognostic Significance of Cuproptosis-Related Genes in Colon Adenocarcinoma.

Colon adenocarcinoma (COAD) is a frequently occurring and lethal cancer. Cuproptosis is an emerging type of cell death, and the underlying pathways involved in this process in COAD remain poorly understood. Transcriptomic and clinical data for COAD patients were collected from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.

The Effects of Interventions with Glucosinolates and Their Metabolites in Cruciferous Vegetables on Inflammatory Bowel Disease: A Review.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract which affects millions of individuals worldwide. Despite advancements in treatment options, there is increasing interest in exploring natural interventions with minimal side effects. Cruciferous vegetables, such as broccoli, cabbage, and radishes, contain bioactive compounds known as glucosinolates (GLSs), which have shown promising effects in alleviating IBD symptoms.

Study on the law of ore dilution and loss and control strategies under brow line failure in sublevel caving mining.

To improve ore recovery ratio and the quality of medium-length hole blasting in non-pillar sublevel caving method, this study first investigated the effects of brow line failure on rock movement and ore recovery indexes based on rock blasting fragmentation mechanisms, the granular dynamics theory and ore drawing theory. Subsequently, control strategies to enhance blasting quality and reduce brow line failure were explored through energy impact crushing experiments, experiments on the radial rock-breaking effects of blast holes with different detonation velocities, and underground physical simulation experiments using full blast hole length detonating cord blasting. The experimental results indicate that as the degree of brow line failure increases, the ore recovery ratio gradually decreases, while the waste ratio gradually increases.

Health-related quality of life and associated factors among children with Transfusion-dependent β-thalassaemia: a cross-sectional study in Guangxi Province.

Background: Transfusion-dependent β-thalassemia (TDT) is a severe inherited disorder. Without regular treatment, patients with TDT experience complications that can significantly shorten life expectancy and severely impact both their quality of life and that of their families. The condition has attracted significant attention in global health discussions.

Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis.

SS18-SSX onco-fusion protein formed through aberrant chromosomal translocation t (X, 18; p11, q11), is the hallmark and plays a critical role in synovial sarcomagenesis. The recent works indicated that both the pathological SS18-SSX tumorigenic fusion and the corresponding intrinsic physiological SS18 protein can form condensates but appear to have disparate properties. The underlying regulatory mechanism and the consequent biological significance remain largely unknown.

Multi-drug resistant Staphylococcus epidermidis from chronic wounds impair healing in human wound model.

Venous leg ulcers (VLUs) represent one of the most prevalent types of chronic wounds characterised by perturbed microbiome and biofilm-forming bacteria. As one of the most abundant skin-commensal, Staphylococcus epidermidis is known as beneficial for the host, however, some strains can form biofilms and hinder wound healing. In this study, S.