The Basilar Artery Collateral Simplified Score: a Novel Collateral Circulation Score Associated With Outcomes in Patients With Basilar Artery Occlusion: Results From the ATTENTION Study.

Background: The aim of the current study was to develop a simplified collateral score for basilar artery occlusion and assess its impact on the relationship between procedure time and outcomes.

Methods And Results: The derivation cohort (n=221) from the ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) study was used. Variables identified by logistic regression were used to develop the Basilar Artery Collateral Simplified Score (BACSS).

Application of chemical pattern recognition and similarity evaluation in electrochemical and HPLC-DAD fingerprints for quality consistency study of herbal medicines.

Background: Herbal medicines and their preparations play a significant role in healthcare systems, yet concerns remain about their quality consistency. Chemical fingerprinting and multi-component quantitative analysis are the commonly used analytical methods and are widely applied in the quality analysis of herbal medicines. The study uses Gegen Qinlian tablets (GQTs) as a case to propose a comprehensive quality consistency evaluation system.

Evaluating quality consistency of Celosiae Cristatae Flos by four dimensional fingerprints combined with antioxidant activity.

Celosiae Cristatae Flos (CCF) has haemostatic and anti-dysentery properties, making it a natural medicine worthy of further development. However, there are few studies on it and most of them are based on high performance liquid chromatography. Consequently, there is a need to develop a comprehensive quality evaluation method based on multiple analytical techniques to reveal the composition of CCF.

Pulley ring suture increases shoulder stability after biceps tendon transposition.

Objective: Modified double-row biceps tenodesis (MDBT) has been proved to be effective in treating slap injuries, but the impact of closing the rotator cuff gap remained postoperatively (the Pulley ring repair) on the long-term shoulder function and stability has not been conclusively investigated.

Methods: A retrospective study was conducted on 157 patients with isolated unilateral type II SLAP lesions treated with MDBT from January 2019 to January 2023. 77 patients were without the Pulley ring repair (group A) and the remaining 80 patients were with the Pulley ring repair (group B).

An quality evaluation method based on three-dimensional integration and machine learning: Advanced data processing.

This study presents an innovative approach for the quality evaluation of traditional Chinese medicine (TCM) by integrating three-dimensional (3D) data processing with machine learning, aimed at enhancing the efficiency and accuracy of HPLC-DAD data analysis. Through 3D data integration, multi-dimensional signals from the time and wavelength domains are transformed into two-dimensional data, simplifying the analytical process while ensuring precise quantification of component contents. Building on this foundation, dynamic time warping (DTW) and correlation optimized warping (COW) algorithms were applied to effectively resolve retention time drift across different sample batches, achieving both global and local alignment of chromatographic peak shapes.

Whole genome insights into genetic diversity, introgression, and adaptation of Yunnan indigenous cattle of Southwestern China.

Background: Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of the region have collectively contributed to shaping the distinctive germplasm characteristics observed in Yunnan indigenous cattle through prolonged domestication. The different breeds of Yunnan cattle exhibit distinct advantageous characteristics and traits, which are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. However, a comprehensive genomic landscape of genetic resources has yet to be delineated.

FedBCD: Federated Ultrasound Video and Image Joint Learning for Breast Cancer Diagnosis.

Ultrasonography plays an essential role in breast cancer diagnosis. Current deep learning based studies train the models on either images or videos in a centralized learning manner, lacking consideration of joint benefits between two different modality models or the privacy issue of data centralization. In this study, we propose the first decentralized learning solution for joint learning with breast ultrasound video and image, called FedBCD.

Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research.

T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and eliminating infected and tumor cells. In tumor immunotherapy, T cells have emerged as a promising therapeutic strategy due to their high specificity, potent cytotoxic capability, long-lasting immune memory, and adaptability within immunotherapeutic approaches. However, tumors can evade the immune system by depleting T cells through various mechanisms, such as inhibitory receptor signaling, metabolic exhaustion, and physical barriers within the tumor microenvironment.

Comprehensive analysis strategy of quality for traditional Chinese medicine compound based on fingerprint technology and quantitative prediction of spectra.

Traditional Chinese medicine compound (TCMC) comes from a wide range of sources, and the complexity of chemical composition leads to differences in quality. Improving quality evaluation standards is the focus as well as the difficulty in its development and application. The traditional fingerprint analysis method has certain limitations for the quality evaluation of TCMC and the judgment of superior and inferior products.

Terahertz programmable metasurface based on solid-state plasma.

Terahertz modulation technology based on programmable metasurfaces can respond in real time to external signals or environmental changes, enabling flexible and adaptive control of terahertz waves. This technology demonstrates significant potential and importance across various fields, including communication, imaging, scientific research, security monitoring, and industrial applications. This paper proposes a terahertz programmable metasurface based on solid-state plasma, utilizing solid-state plasma devices to achieve dynamic control of properties such as the amplitude and phase of terahertz waves.

Study on gene expression in the liver at various developmental stages of human embryos.

Background: The normal development of the liver during human embryonic stages is critical for the functionality of the adult liver. Despite this, the essential genes, biological processes, and signal pathways that drive liver development in human embryos remain poorly understood.

Methods: In this study, liver samples were collected from human embryos at progressive developmental stages, ranging from 2-month-old to 7-month-old.

Comparative Study on Sedative and Hypnotic Effects of Crude and Parched Semen Ziziphi Spinosae: Integration of Network Pharmacology and In Vivo Pharmacological Evaluation.

Objective: This study aimed to investigate the medicinal properties of SZS before and after processing and provide novel insights into its potential for treating insomnia.

Methods: This study employed the network pharmacology platform to gather information on the chemical composition of SZS, human targets, genes, molecular networks, and pathways associated with insomnia treatment using SZS. Liquid chromatography-tandem mass spectrometry (LC-MS/ MS) was utilized to analyze the chemical profiles of crude SZS, parched SZS, and their combined decoction.

The Clinical Outcomes of Arthroscopic Tenotomy versus Tenodesis with Medium-to-Massive Rotator Cuff Tear in the Elderly: A Retrospective Study.

Purpose: Shoulder arthroscopic repair of rotator cuff tears with simultaneous treatment of lesions of the long head of the biceps tendon has become increasingly accepted. However, the clinical outcomes between tenotomy and tenodesis remain unclear. This study aimed to compare the efficacy of tenotomy and tenodesis combined with rotator cuff repair in elderly patients with medium-to-massive rotator cuff tears.

Simultaneous nitrogen removal and phosphorus recovery in granular sludge-based partial denitrification/anammox-hydroxyapatite precipitation (PD/A-HAP) process under low C/N ratio and dissolved oxygen limitation.

This study integrates partial denitrification/Anammox (PD/A) with hydroxyapatite (HAP) crystallization in a single reactor, achieving simultaneous nitrogen and phosphorus removal along with phosphorus recovery. By adjusting pH, sludge concentration, low COD/TN ratio, and applying moderate dissolved oxygen stress, the system operated stably and promoted the synergistic growth of HAP and biomass. Results showed a nitrogen removal efficiency (NRE) of 94.

Mechanosensitive Ca channel TRPV1 activated by low-intensity pulsed ultrasound ameliorates acute kidney injury through Notch1-Akt-eNOS signaling.

Acute Kidney Injury (AKI) is a significant medical condition characterized by the abrupt decline in kidney function.Low-intensity pulsed ultrasound (LIPUS), a non-invasive therapeutic technique employing low-intensity acoustic wave pulses, has shown promise in promoting tissue repair and regeneration. A novel LIPUS system was developed and evaluated in rat AKI models, focusing on its effects on glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), and the Notch1-Akt-eNOS signaling pathway.

Skillful seasonal predictions of continental East-Asian summer rainfall by integrating its spatio-temporal evolution.

Skillful seasonal climate prediction is critical for food and water security over the world's heavily populated regions, such as in continental East Asia. Current models, however, face significant difficulties in predicting the summer mean rainfall anomaly over continental East Asia, and forecasting rainfall spatiotemporal evolution presents an even greater challenge. Here, we benefit from integrating the spatiotemporal evolution of rainfall to identify the most crucial patterns intrinsic to continental East-Asian rainfall anomalies.

Quality prediction of air-cured cigar tobacco leaf using region-based neural networks combined with visible and near-infrared hyperspectral imaging.

Visible and Near-infrared hyperspectral imaging (VNIR-HSI) combined with machine learning has shown its effectiveness in various detection applications. Specifically, the quality of cigar tobacco leaves undergoes subtle changes due to environmental differences during the air-curing phase. This study aims to evaluate the feasibility of deep learning methods in overcoming data limitations to develop a VNIR-HSI prediction model for the quality of cigar tobacco leaves at different air-curing levels.

Neuroprotective Effect of 1α,25-Dihydroxyvitamin D3 Against Cognitive Impairment in d-Galactose-Induced Aging Mice.

Aging and age-related cognitive impairment have emerged as a growing global public health concern, yet there are no effective preventive strategies. Excessive oxidative stress and neuroinflammation have been proven to contribute to cognitive decline. Vitamin D maintains the redox balance and exerts immunomodulatory effects, but the specific role of vitamin D in aging and age-related cognitive impairment remains elusive.

[Review of chemical constituents and pharmacological effects of Dendrobium huoshanense and prediction of its Q-markers].

Dendrobium huoshanense is well known for the effects of benefiting stomach, promoting fluid production, clearing heat, and nourishing Yin. Modern pharmacological studies have demonstrated the anti-tumor, blood glucose-lowering, anti-inflammatory, and liver-protecting effects of D. huoshanense.

Deferoxamine functionalized alginate-based collagen composite material enhances the integration of metal implant and bone interface.

Poor osseointegration markedly compromises the longevity of prostheses. To enhance the stability of titanium implants, surface functionalization is a proven strategy to promote prosthesis-bone integration. This study developed a hydrogel coating capable of simultaneous osteoangiogenesis and vascularization by incorporating deferoxamine (DFO) into a sodium alginate mineralized collagen composite hydrogel.

CO laser treatment for scars after cleft lip surgery: a systematic review and meta-analysis.

Background: Current studies are controversial on the optimal treatment of postoperative scar treatment by cleft lip. Our objective is to elucidate the therapeutic effect of CO laser on postoperative cleft lip scar treatment.

Methods: A systematic review was performed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Symptoms and negative emotions in patients with advanced thyroid cancer: a prospective cross-sectional study.

Background: There is no relevant research on the symptoms and emotions of patients with advanced thyroid cancer in mainland China.

Aim: To investigate the symptoms and negative emotions of patients with advanced thyroid cancer and to analyze the correlation between the two preliminarily.

Methods: Using a convenience sampling method, 180 patients who visited a multidisciplinary outpatient service for advanced thyroid cancer at West China Hospital of Sichuan University from January 2023 to December 2023 were selected as the research subjects.

Chromosome-level genome assembly of banaba (Lagerstroemia speciosa L.).

Lagerstroemia speciosa is a famous medicinal and ornamental plant of the Lagerstroemia genus, with large and gorgeous flowers and a flowering period of 3 to 5 months. L. speciosa extracts have been used for many years in folk medicine to treat diabetes.

Floral Elegance Meets Medicinal Marvels: Traditional Uses, Phytochemistry, and Pharmacology of the Genus L.

The genus L. (Lythraceae), known for its exquisite flowers and prolonged flowering period, is commonly employed in traditional medicinal systems across Asian countries, where it has always been consumed as tea or employed to address ailments such as diabetes, urinary disorders, coughs, fevers, inflammation, pain, and anesthesia. Its diverse uses may be attributed to its rich active ingredients.