Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study.

Background: The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate. Hence, the objective of this study is to evaluate the impact of lipid-lowering medications on the occurrence risk of OC and CC through Mendelian randomization (MR) analysis of drug targets.

Methods: This investigation concentrated on the primary targets of lipid-lowering medications, specifically, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and proprotein convertase kexin 9 (PCSK9).

COPD and T2DM: a Mendelian randomization study.

Introduction: Type 2 diabetes (T2DM) stands as a global chronic illness, exerting a profound impact on health due to its complications and generating a significant economic burden. Recently, observational studies have pointed toward a potential link between Chronic Obstructive Pulmonary Disease (COPD) and T2DM. To elucidate this causal connection, we employed the Mendelian randomization analysis.

Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways.

Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal transition (EMT) is an essential player in these alterations. Scutellarin is isolated from Erigeron breviscapus.

Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.

Ethnopharmacological Relevance: Acute lung injury (ALI) is a life-threatening and widespread disease, with exceptionally high morbidity and mortality rates. Unfortunately, effective drugs for ALI treatment are currently lacking. Guben Qingfei decoction (GBQF) is a Chinese herbal compound known for its efficacy in treating viral pneumonia, yet the precise underlying mechanisms remain unknown.

A large pericardial cyst mimicking a unilateral pleural effusion: A case report.

Rationale: Pericardial cysts are a rare benign disorder with a variable clinical presentation depending on their size and location. The diagnosis of pericardial cysts is usually based on imaging examinations. The definitive treatment is surgical resection.

Dual-mode frequency multiplier in graphene-base hot electron transistor.

Since quantum computers have been gradually introduced in countries around the world, the development of the many related quantum components that can operate independently of temperature has become more important for enabling mature products with low power dissipation and high efficiency. As an alternative to studying cryo-CMOSs (complementary metal-oxide-semiconductors) to achieve this goal, quantum tunneling devices based on 2D materials can be examined instead. In this work, a vertical graphene-based quantum tunneling transistor has been used as a frequency modulator.

The relationship of marital adjustment and posttraumatic growth in female breast cancer patients and their husbands.

Posttraumatic growth (PTG) is very important for breast cancer couples to cope with cancer. Individual marital adjustment can affect PTG, however, it is still unknown that the effect of marital adjustment on one's own and their spouses' PTG in breast cancer couples. To investigate the status of PTG and marital adjustment and explore the relation between PTG and marital adjustment in breast cancer patient-husband dyads.

Incidence, aetiology and clinical features of eosinophilic pleural effusion: a retrospective study.

Background: Eosinophilic pleural effusion (EPE) is a distinct entity among pleural effusions, but its diagnostic and prognostic significance is still controversial. This study aimed to evaluate the incidence and aetiological distribution of EPE in our institution and to assess the relationship between EPE and malignancy and other underlying diseases and the relevance of the percentage of eosinophils and other laboratory parameters.

Methods: A retrospective study was conducted by reviewing the medical records of 252 patients with PE from September 2017 to January 2021.

Core-shell Cu@C@ZIF-8 composite: a high-performance electrode material for electrochemical sensing of nitrite with high selectivity and sensitivity.

Herein, an efficient electrochemical sensing platform is proposed for selective and sensitive detection of nitrite on the basis of Cu@C@Zeolitic imidazolate framework-8 (Cu@C@ZIF-8) heterostructure. core-shell Cu@C@ZIF-8 composite was synthesized by pyrolysis of Cu-metal-organic framework@ZIF-8 (Cu-MOF@ZIF-8) in Ar atmosphere on account of the difference of thermal stability between Cu-MOF and ZIF-8. For the sensing system of Cu@C@ZIF-8, ZIF-8 with proper pore size allows nitrite diffuse through the shell, while big molecules cannot, which ensures high selectivity of the sensor.

Improving the Fenton-like catalytic performance of MnO-FeO/biochar using reducing agents: A comparative study.

In this work, a Fenton-like system with MnO-FeO/biochar composite (FeMn/biochar) and reducing agents (RAs) was constructed for pollutant degradation, aiming to enhance Fenton-like performance from both degradation efficacy and operational cost aspects. Batch experiments revealed that five well-characterized RAs (sodium borohydride (SBH), sodium thiosulfate (STS), ascorbic acid (AA), hydroxylamine (HA) and oxalic acid (OA)) could impact performance of FeMn/biochar-HO system through multiple mechanisms, including variation of solution pH, competition for HO, electrostatic attraction and acceleration of metal redox cycle. Significantly, only OA and HA obviously enhanced the catalytic capacity of Fenton-like process and HA increased ciprofloxacin degradation efficiency from 38.

Mxene/carbon nanohorn/β-cyclodextrin-Metal-organic frameworks as high-performance electrochemical sensing platform for sensitive detection of carbendazim pesticide.

Pesticides play an important role in agricultural fields, but the pesticide residues pose strong hazardous to human health, thus designing sensitive and fast method for pesticides monitor is highly urgent. Herein, nanoarchitecture of Mxene/carbon nanohorns/β-cyclodextrin-Metal-organic frameworks (MXene/CNHs/β-CD-MOFs) was exploited as electrochemical sensing platform for carbendazim (CBZ) pesticide determination. β-CD-MOFs combined the properties of host-guest recognition of β-CD and porous structure, high porosity and pore volume of MOFs, enabling high adsorption capacity for CBZ.

Is F-FDG PET/CT useful for diagnosing relapsing polychondritis with airway involvement and monitoring response to steroid-based therapy?

Background: F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a promising tool for diagnosing relapsing polychondritis (RP). However, its usefulness in assessing RP with airway involvement is unknown.

Objective: This study aimed to further evaluate and confirm the potency of F-FDG PET/CT in diagnosing RP with airway involvement and monitoring response to steroid-based therapy.

Anchoring single-unit-cell defect-rich bismuth molybdate layers on ultrathin carbon nitride nanosheet with boosted charge transfer for efficient photocatalytic ciprofloxacin degradation.

Photocatalysis technology is regarded as a promising way for environmental remediation, but rationally designing photocatalysis system with high-speed interfacial charge transfer, sufficient photoabsorption and surface reactive sites is still a challenge. In this study, anchoring single-unit-cell defective BiMoO on ultrathin g-CN to form 2D/2D heterostructure system is a triple-purpose strategy for high-performance photocatalysis. The defect structure broadens photo-responsive range.

Recent development of advanced biotechnology for wastewater treatment.

The importance of highly efficient wastewater treatment is evident from aggravated water crises. With the development of green technology, wastewater treatment is required in an eco-friendly manner. Biotechnology is a promising solution to address this problem, including treatment and monitoring processes.

Electrochemical biosensor for amplified detection of Pb based on perfect match of reduced graphene oxide-gold nanoparticles and single-stranded DNAzyme.

In this study, a sensitive amplification strategy for Pb detection using reduced graphene oxide (RGO) and gold nanoparticles (AuNPs) was proposed. Thiol-modified DNAzyme is specific for Pb self-assembly on RGO-AuNPs-modified electrode surface. Ferrocene labeled single-stranded DNAzyme (Fc-ssDNAzyme) self-hybridizes to form a DNA hairpin structure.

Ultrathin oxygen-vacancy abundant WO decorated monolayer BiWO nanosheet: A 2D/2D heterojunction for the degradation of Ciprofloxacin under visible and NIR light irradiation.

At present, environmental pollution caused by refractory organic pollutants becomes more serious. Semiconductor-based photocatalysis technology, an idea and continuable technology by solar-light-driven, is widely employed to address this situation. Here, oxygen-vacancy rich WO decorated monolayer BiWO nanosheet composite as an atomic scale heterojunction with high active species and ultrafast charge carrier transfer was rationally constructed.

Multiple charge-carrier transfer channels of Z-scheme bismuth tungstate-based photocatalyst for tetracycline degradation: Transformation pathways and mechanism.

As a sustainable and cost-efficient technique, photocatalytic technology provides an ideal method for energy utilization and environmental pollution control. The current photocatalyst is commonly based on single charge transfer approach, which cannot meet the demand of rapidly charge transfer to improve the photocatalytic performance. Herein, a novel AgPO/MWCNT/BiWO Z-scheme heterojunction photocatalyst with multiple charge-carrier transfer channels was successfully prepared by a simple hydrothermal and deposition procedure, which possessed remarkable charge carriers separation efficiency and broad photoabsorption: (i) Z-scheme charge transfer channel was formed by AgPO, BiWO and Ag; (ii) Ag showed the "electron sink" property and surface plasmon resonance (SPR) effect; (iii) multi-walled carbon nanotube (MWCNT) can act as electron accepter to improve the transfer efficiency of photoinduced electron.

Degradation of naphthalene with magnetic bio-char activate hydrogen peroxide: Synergism of bio-char and Fe-Mn binary oxides.

This study investigated the hydrogen peroxide (HO) activation potential of Fe-Mn binary oxides modified bio-char (FeMn/bio-char) for the degradation of naphthalene, the dominant PAHs in drinking water. Results showed that FeMn/bio-char exhibited 80.7- and 2.

Micro gel column technique is fit for detecting mixed fields post ABO incompatible hematopoietic stem cell transplantation.

How to choose suitable serologic method for assessment of the actual stages of ABO chimera is more important to establish transfusion strategy for patients post-ABO incompatible hematopoietic stem cell transplantation. We reported ABO phenotypes of a patient post-ABO minor incompatible hematopoietic stem cell transplantation from 1+ weak agglutination by tube method was obviously reaffirmed to mixed fields with 4+ positive reaction by micro gel column card. Hence, blood bank technologists must continually work together with hematologist to establish appropriate transfusion strategy, and micro gel column technique can be more appropriate for detecting mixed fields during the whole period of transplantation.

[Effects of tumor metastasis suppressor gene nm23-H1 on invasion and proliferation of cervical cancer cell lines].

Background And Objective: Previous studies have shown that nm23-H1 is a tumor metastasis suppressor gene. Nucleotide diphosphate kinase 1 (NDPK1) encoded by nm23-H1 is involved in cancer cellular differentiation, proliferation, apoptosis and metastasis. This study was to investigate the effects of nm23-H1 on proliferation and invasion of cervical cancer cells.

Chitosan/pshRNA plasmid nanoparticles targeting MDR1 gene reverse paclitaxel resistance in ovarian cancer cells.

In order to investigate the effect of chitosan/pshRNA plasmid nanoparticles targeting MDR1 genes on the resistance of A2780/TS cells to paclitaxel, chitosan/pshRNA plasmid nanoparticles were synthesized by means of a complex coacervation technique and transfected into A2780/TS cells. The cells transfected with MDR1-targeted chitosan/pshRNA plasmid nanoparticles were experimental cells and the cells transfected with chitosan/pGPU6/GFP/Neo no-load plasmid nanoparticles served as negative control cells. Morphological features of the nanoparticles were observed under transmission electron microscope (TEM).