Publications by Minetsugu Yasuda

Publications by authors named "Minetsugu Yasuda"

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Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.

Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda

Arterioscler Thromb Vasc Biol

October 2008

Objective: High mobility group box 1 protein (HMGB1) was identified as a mediator of endotoxin lethality. We previously reported that thrombomodulin (TM), an endothelial thrombin-binding protein, bound to HMGB1, thereby protecting mice from lethal endotoxemia. However, the fate of HMGB1 bound to TM remains to be elucidated.

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