Publications by authors named "Minerva Sewer"

Standardized allergen vaccines have been developed and registered as biopharmaceutical products in Cuba. Three different vaccines were obtained from the most relevant allergenic mite species: Dermatophagoides pteronvssinus, Dermatophagoides siboney, and Blomia tropicalis. Immuno-analytical methods based on murine monoclonal antibodies and human IgE antibodies were developed for assessing allergenic potency, composition, and stability.

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Article Synopsis
  • The study focused on a recombinant allergen, rBlo t 13, which shows some reactivity to IgE in allergic patients and is part of a protein family related to fatty acid-binding.
  • Researchers generated monoclonal antibodies (MAbs) by immunizing mice with rBlo t 13 from a yeast expression system and used various techniques to test these antibodies for specificity and reactivity with natural allergens.
  • Two specific MAbs were successfully created that recognize rBlo t 13, demonstrating potential cross-reactivity with similar allergens in another species, Dermatophagoides siboney.
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