Splice variants of zinc finger protein 695 mRNA associated to ovarian cancer.

Background: Studies of alternative mRNA splicing (AS) in health and disease have yet to yield the complete picture of protein diversity and its role in physiology and pathology. Some forms of cancer appear to be associated to certain alternative mRNA splice variants, but their role in the cancer development and outcome is unclear.

Methods: We examined AS profiles by means of whole genome exon expression microarrays (Affymetrix GeneChip 1.

The cervical malignant cells display a down regulation of ER-α but retain the ER-β expression.

The human cervix is a tissue target of sex steroid hormones as estradiol (E2) which exerts its action through of the estrogen receptors alpha and beta (ER-α and ER-β). In this study we investigated the expression of ER-α and ER-β in human invasive cervical carcinomas using immunohistochemistry and RT-PCR analyses and compared with that observed in the corresponding normal tissue. The results show nuclear expression of ER-α mainly in the first third of normal cervical epithelium, however, decreased or absent expression were present in invasive cervical carcinoma, indicating that expression of ER-α is lost in cervical cancer.

IgG4-related multiorgan disease: report of the first autopsy case.

IgG4-related disease (IgG4RD) is a chronic recurring fibro-inflammatory pathology that is considered to be of autoimmune origin. Histopathology is considered to be the gold standard method for diagnosis. IgG4RD affects multiple organs.

Hox B4 as potential marker of non-differentiated cells in human cervical cancer cells.

Background: Cervical cancer (CC) is a common malignancy in women worldwide. Cervical tumorigenesis involves a multistep process in which accumulations of genetic alterations are present. Homeotic genes, such as HOX gene re-expression, have been reported in a wide variety of tumors.

[Synchronic hepatocellular carcinoma with atrial myxoma. A case report].

The case of a 60-year-old woman with history of cryptogenic hepatic cirrhosis and a probable hepatic tumor, who died of upper gastrointestinal bleeding secondary to esophageal varices, is presented. An autopsy study was carried out, which showed a hepatocellular carcinoma and a left atrial cardiac myxoma with glandular elements. A review of the literature, searching for the association between these two tumors, in addition to other tumors, is presented.