Publications by authors named "Mineko Mochizuki"
Tea catechins have strong bitterness and influence the taste of tea. Among the 25 human bitter-taste receptors (TAS2Rs), we found that hTAS2R14 responded to catechins, in addition to hTAS2R39, a known catechin receptor. Although hTAS2R14 responded to (-)-epicatechin gallate and (-)-epigallocatechin gallate, it did not respond to (-)-epicatechin and (-)-epigallocatechin.
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- - A series of novel compounds were developed that feature specific chemical structures, designed for potential cancer treatment, and were tested for their effectiveness against cancer cell lines.
- - Specific compounds containing the 3-chloropyridin-2-yl and 3-fluoro-5-substituted phenylpiperazinyl groups demonstrated strong cytotoxic activity in lab tests.
- - Among these, the 3-cyano-5-fluorophenyl derivative (29b) showed impressive antitumor effects on various cancer cells, including human carcinoma, while being safe for use in mice.