Publications by authors named "Mine Sebnem Karakan"
Background: It is thought that the Fracture Risk Assessment Tool (FRAX) score of the World Health Organization (WHO) determines a 10-year fracture risk. This study aimed to investigate the major osteoporotic fracture (MOF) and hip fracture (HF) values determined with the FRAX score and practicality of the FRAX score in kidney transplant recipients (KTRs).
Methods: This study was conducted with 44 female and 59 male KTRs and 100 subjects in the healthy control group.
Introduction: Dickkopf wingless (Wnt) signaling pathway inhibitor-1 (DKK-1) is a potent antagonist of the WNT canonical signaling pathway. DKK-1 is a substance that exerts anabolic effects on bone and is also involved in vascular cell regulation. The study aimed to determine the relationship of DKK-1 with atherosclerosis as determined by carotid artery intima-media thickness (CA-IMT) and arterial stiffness (AS) as determined by brachial-ankle pulse wave velocity (baPWV) in renal transplant recipients (RTRs).
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- * Out of 90 RTR participants, the median antibody level was 16.7 AU/mL at 42 days post-first dose, with 60% showing positive serology; mycophenolic acid (MFA) and ACE inhibitors were found to decrease seropositivity.
- * Patients who received the Pfizer/BioNTech booster had better antibody levels and lower COVID-19 infections compared to those with the CoronaVac/Sinovac booster, indicating that heterologous vaccination is more effective for RTRs.
Article Synopsis
- The study examines how Angiopoietin-2 (Ang-2) and Vascular Endothelial Growth Factor (VEGF) relate to atherosclerosis in renal transplant recipients (RTRs) compared to healthy individuals.
- Conducted at Ankara City Hospital, the research involved 96 RTRs and 70 healthy controls, measuring carotid artery thickness and renal resistive index as indicators of atherosclerosis.
- Results showed higher levels of Ang-2 and VEGF in RTRs, but no significant relationship between these growth factors and measures of atherosclerosis was found.
Objectives: Thiols play an important role in defense against reactive oxygen species. We aimed to evaluate the relation between oxidative stress, glucose tolerance, and sleep quality in kidney transplant recipients without diabetes.
Materials And Methods: We enrolled 95 kidney transplant recipients without diabetes from living and deceased donors with stable allograft function and 60 healthy controls.
Objectives: We evaluated the effects of body composition on graft function and cardiovascular outcomes in normotensive renal transplant recipients.
Materials And Methods: In this cross-sectional study, we analyzed ambulatory blood pressure monitoring data from 136 renal transplant recipients with stable allograft function after living related donor transplant. We enrolled 87 normotensive recipients.
Article Synopsis
- This study investigates the impact of COVID-19 preventive measures on renal transplant recipients, as no previous research has addressed this issue.
- A survey conducted two months after the first COVID-19 case in Turkey found that 95.5% of 68 surveyed patients practiced isolation, wore masks, and increased hand hygiene.
- The results indicated that the majority adhered to these preventive practices, with no infections reported among the participants, suggesting that their compliance effectively mitigated the risk of COVID-19.
Article Synopsis
- The study investigates the connection between serum levels of Fibroblast Growth Factor-23 (FGF23) and cardiovascular issues and early graft failure in kidney transplant patients.
- Researchers divided 88 kidney transplant recipients into two groups based on their FGF23 levels and used Doppler ultrasounds to measure atherosclerosis and graft health.
- Results showed that higher FGF23 levels correlate with worse cardiovascular health and graft function, suggesting FGF23 could serve as a useful biomarker for monitoring these risks in kidney transplant recipients.
Article Synopsis
- Chronic kidney disease (CKD) is a significant health concern that can lead to severe outcomes like renal failure and heart issues, and researchers are investigating the role of the neutrophil to lymphocyte ratio (NLR) as a marker of inflammation related to kidney function.
- This study analyzed patient data from those who had partial or radical nephrectomy, dividing them into four distinct groups to compare NLR levels among healthy individuals and various stages of kidney disease.
- The findings revealed that NLR was significantly lower in healthy controls compared to CKD patients, and it showed a negative correlation with kidney function (GFR) and a positive correlation with CKD stage, suggesting that NLR could be a useful predictor of kidney health post