maintains two ohnologs, and , for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions.

Unlabelled: exhibits innate resistance to azole antifungal drugs but also has the propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is one of the major classes of antifungals used to treat infections. Despite their widespread use, the mechanism controlling azole-induced gene expression and drug resistance in has primarily revolved around Upc2 and/or Pdr1.

maintains two Hap1 homologs, Zcf27 and Zcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions.

exhibits innate resistance to azole antifungal drugs but also has the propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is one of the three major classes of antifungals used to treat infections. Despite their widespread use, the mechanism controlling azole-induced gene expression and drug resistance in has primarily revolved around Upc2 and/or Pdr1.