Publications by authors named "Mincheng Lu"
Article Synopsis
- The study explores brain-bone crosstalk, which is the communication between the brain and bones, and how disruptions can lead to conditions like osteoporosis.
- Researchers found that Staphylococcus aureus lipoteichoic acid activates specific receptors in the brain, which affects the production of prostaglandin E2 (PGE2) and influences bone health.
- PGE2 enhances the secretion of growth hormone, which helps counteract age-related bone loss, highlighting the importance of understanding these interactions for bone disease management.
Article Synopsis
- - Aging leads to osteoporosis, a widespread degenerative disease, with type H blood vessels being crucial for both bone and blood vessel formation; their decline in older age is linked to bone loss, but the exact mechanisms are still unclear.
- - A study used various mouse models and techniques like micro-CT scans and histological staining to assess bone structure and type H vessels, along with testing human endothelial cells for vascular functions under different treatments.
- - The research focused on understanding how FOXO1, a protein implicated in aging processes, affects type H vessels and bone health, using methods like gene analysis, pharmacological interventions, and the creation of genetically modified mice.
Osteomyelitis is a chronic inflammatory bone disease caused by infection of open fractures or post-operative implants. Particularly in patients with open fractures, the risk of osteomyelitis is greatly increased as the soft tissue damage and bacterial infection are often more severe. , one of the most common pathogens of osteomyelitis, disrupts the immune response through multiple mechanisms, such as biofilm formation, virulence factor secretion, and metabolic pattern alteration, which attenuates the effectiveness of antibiotics and surgical debridement toward osteomyelitis.
View Article and Find Full Text PDFApolipoprotein E deficiency potentiates macrophage against in mice with osteomyelitis via regulating cholesterol metabolism.
Front Cell Infect Microbiol
August 2023
Introduction: () osteomyelitis causes a variety of metabolism disorders in microenvironment and cells. Defining the changes in cholesterol metabolism and identifying key factors involved in cholesterol metabolism disorders during osteomyelitis is crucial to understanding the mechanisms of osteomyelitis and is important in designing host-directed therapeutic strategies.
Methods: In this study, we conducted and experiments to define the effects of osteomyelitis on cholesterol metabolism, as well as the role of Apolipoprotein E (ApoE) in regulating cholesterol metabolism by macrophages during osteomyelitis.
Objective: To evaluate the clinical value of diabetes mellitus for diagnosis and postoperative prognosis in patients with cervical spondylotic myelopathy undergoing anterior decompression and fusion.
Methods: A total of 84 Patients (50 males and 34 females) who underwent anterior decompression and fusion were reviewed in this single-center retrospective study. The patients were divided into two groups (44 patients in the diabetes mellitus group and 40 in the non-diabetic group).