Color stability, surface, and physicochemical properties of three-dimensional printed denture base resin reinforced with different nanofillers.

Various materials have been introduced for the three-dimensional (3D) printing of dentures. In this study, the color stability and surface and physicochemical properties of 3D-printed denture base resins with four types of nanofiller particles were evaluated. AlO, ZnO, CeZr, and SiO nanofillers were added to a 3D printable denture base-resin matrix and subjected to digital light processing.

CD4 cytotoxic T cells: an emerging effector arm of anti-tumor immunity.

While CD8 cytotoxic T cells have long been considered the primary effector in controlling tumors, the involvement of CD4 "helper" T cells in anti-tumor immunity has been underappreciated. The investigations of intra-tumoral T cells, fueled by the recent advances in genomic technologies, have led to a rethinking of the indirect role of CD4 T cells that have traditionally been described as a "helper". Accumulating evidence from preclinical and clinical studies indicates that CD4 T cells can acquire intrinsic cytotoxic properties and directly kill various types of tumor cells in a major histocompatibility complex class II (MHC-II)-dependent manner, as opposed to the indirect "helper" function, thus underscoring a potentially critical contribution of CD4 cytotoxic T cells to immune responses against a wide range of tumor types.

Significant paradigm of beauty ecosystem after COVID-19 pandemic in Republic of Korea.

Background: The beauty industry, one of the face-to-face the essential industries in the COVID-19 pandemic, has been hit hard.

Aims: We present the current state of the beauty ecosystem in the corona pandemic and the future direction of the beauty industry after COVID-19.

Methods: This review paper is a literature review, and a descriptive review approach was used in this study.

Mitogen-Activated Protein Kinase Functions as a Positive Regulator of Drought Stress Response and Abscisic Acid Signaling in .

Protein phosphorylation by kinase is an important mechanism for adapting to drought stress conditions. Here, we isolated the () from dehydrated pepper leaf tissue and functionally characterized it. Subcellular localization analysis revealed that the CaDIMK1 protein was localized in the cytoplasm and nucleus.

Phase I and pharmacokinetic study of the vascular-disrupting agent CKD-516 (NOV120401) in patients with refractory solid tumors.

We report a phase I pharmacological study of an oral formulation of CKD-516, a vascular-disrupting agent, in patients with refractory solid tumors. Twenty-seven patients (16 in the dose-escalation cohort and 11 in the expansion cohort) received a single daily dose (5-25 mg) of CKD-516 five days per week. Nausea (67%) and diarrhea (63%) were the most common treatment-related adverse events.

Cellular Behavior of RAW264.7 Cells in 3D Poly(ethylene glycol) Hydrogel Niches.

Although macrophages undergo dynamic cellular responses in diverse extracellular environments, macrophage research has mostly relied on conventional culture methodologies such as two-dimensional and suspension cultures. In contrast, recent efforts have revealed evidence of the characteristic cellular behaviors of macrophages in actual tissues using a three-dimensional (3D) culture matrix. In this work, we exploited a poly(ethylene glycol)-based hydrogel as a macrophage culture matrix and observed cellular behaviors in 3D by manipulating the matrix properties.

β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.

β-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of β-thujaplicin in regulating mammary tumorigenesis has not been investigated. In this study, we found that β-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor α (ER-α) was down-regulated by β-thujaplicin via enhanced proteolysis by ubiquitination, which led to cell growth inhibition.