Five new triterpenoids isolated from mastic: Structural identification and their anti-inflammatory activity.

Five new oleanane-type triterpenoids were isolated from mastic. Their structures including absolute configurations were determined by extensive spectroscopic methods and single-crystal X-ray crystallographic experiments. Compound 1 is distinguished by its rare furan ring.

Crystallization in load-controlled shearing flows of monosized spheres.

Identical, inelastic spheres crystallize when sheared between two parallel, bumpy planes under a constant load larger than a minimum value. We investigate the effect of the inter-particle friction coefficient of the sheared particles on the flow dynamics and the crystallization process with discrete element simulations. If the imposed load is about the minimum value to observe crystallization in frictionless spheres, adding small friction to the granular assembly results in a shear band adjacent to one of the planes and one crystallized region, where a plug flow is observed.

Assessment of uterine caruncles, uterine cervix, and vulva during the postpartum period in Kivircik ewes with shear-wave elastography.

Introduction: This study aims to quantify the shear wave speed (SWS) and stiffness of the uterine cervix (close to the internal cervical ostium (IOC) which is the cranial portion of cervix and close to the external cervical ostium (EOC) which is the caudal portion of cervix), caruncular areas, and vulvar labia during the postpartum period in healthy Kivircik ewes by using shear-wave elastography. Power Doppler ultrasonography was performed to evaluate the color pixel percentage (CPP) of the caruncles.

Methods: The study included 13 healthy pregnant Kivircik ewes, which were randomly selected.

Usefulness of differential somatic cell count for udder health monitoring: association of differential somatic cell count and somatic cell score with quarter-level milk yield and milk components.

Mastitis is the most common disease affecting dairy cattle and is associated with substantial milk loss. Somatic cell count (SCC) has been widely used as an indicator of udder inflammation (e.g.

Spatio-temporal analysis of litterfall load in the lower reaches of Qarqan and Tarim rivers using BP neural networks.

Litterfall load is crucial in maintaining ecosystem health, controlling wildfires, and estimating carbon stock in arid regions. However, there is a lack of spatiotemporal analysis of litterfall in arid riparian forests. This study aims to estimate Litterfall load using a BP neural network based on vegetation indices from Landsat 5 and 8 satellite images, litterfall inventory data, slope, and distance to major river tributaries.

Evaluation of calcium, phosphorus and some biochemical parameters in dogs with open and closed cervix pyometra.

The aim of this study was to evaluate the changes in calcium, phosphorus and some biochemical parameters in dogs with open and closed cervix pyometra, which was then compared with a control group. A total of 62 bitches of age group 5-10 years old irrespective of breed were enrolled into the study. Control group consisted of 22 bitches which were clinically healthy and in luteal phase of the estrus cycle.

A reinforcement learning approach to effective forecasting of pediatric hypoglycemia in diabetes I patients using an extended de Bruijn graph.

Pediatric diabetes I is an endemic and an especially difficult disease; indeed, at this point, there does not exist a cure, but only careful management that relies on anticipating hypoglycemia. The changing physiology of children producing unique blood glucose signatures, coupled with inconsistent activities, e.g.

Usefulness of differential somatic cell count for udder health monitoring: effect of intramammary infections, days in milk, quarter location, and parity on quarter-level differential somatic cell count and somatic cell score in apparently healthy dairy cows.

Microbial infections of the mammary gland often cause mastitis, and it can lead to substantial economic losses within the dairy industry due to its direct negative impact on milk production and composition and the associated treatment costs. Somatic cell count has emerged as a critical indicator in monitoring udder health, and recently, the large-scale availability of differential cell count analysis potentially offers new insights into underlying physiological processes. Therefore, the main objective of this study was to estimate the variation of DSCC and SCC of individual quarter-level milk samples of cows according to 1) their intramammary infectious status; 2) parity of the cow; 3) quarter location; and 4) DIM at the time of sampling.

Usefulness of differential somatic cell count for udder health monitoring: Identifying referential values for differential somatic cell count in healthy quarters and quarters with subclinical mastitis.

Mastitis, an inflammation of the udder primarily caused by an intramammary infection, is one of the most common diseases in dairy cattle. Somatic cell count (SCC) has been widely used as an indicator of udder inflammation, assisting in the detection of subclinical mastitis. More recently, differential somatic cell count (DSCC), which represents the combined proportion of lymphocytes and polymorphonuclear leukocytes, has become available for routine dairy milk screening, though it was not yet widely studied.

Usefulness of differential somatic cell count for udder health monitoring: Diagnostic performance of somatic cell count, and differential somatic cell count for diagnosing of intramammary infections in dairy herds with automated milking systems.

Mastitis poses significant economic challenges for dairy farms. Therefore, enhancing the accuracy of diagnostic methods for detecting intramammary infections (IMI) can potentially improve prevention, control and treatment strategies. The somatic cell count (SCC) is a well-established parameter for identifying inflammation resulting from IMI.

Evaluating the Efficacy of Combined Platelet-Rich Plasma and Microneedling for Aesthetic Rejuvenation of the Periorbital Area: A Randomized, Blinded Cohort Study.

Introduction: Microneedling, a technique involving controlled dermal microwounding, and platelet-rich plasma (PRP) injections are both employed for skin rejuvenation. While both treatments individually show promise, limited research has explored their combined efficacy. This study aimed to evaluate the effectiveness of combining PRP injections with microneedling for aesthetic concerns around the eyes under standardized conditions.

Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system.

Targeted proteomics of cerebrospinal fluid in treatment naïve multiple sclerosis patients identifies immune biomarkers of clinical phenotypes.

Multiple sclerosis (MS) is an inflammatory demyelinating disease with heterogeneous clinical presentations and variable long-term disability accumulation. There are currently no standard criteria to accurately predict disease outcomes. In this study we investigated the cross-sectional relationship between disease phenotype and immune-modulating cytokines and chemokines in cerebrospinal fluid (CSF).

The occurrence of and non-aureus staphylococci in raw milk negatively correlates with clinical mastitis.

is a common environmental pathogen associated with clinical mastitis (CM) in dairy cattle. There is an interest in optimizing the udder microbiome to increase the resistance of dairy cattle to CM; however, the details of which members of the healthy udder microbiome may play a role in antagonizing are unknown. In this study, we characterized the bacterial community composition in raw milk collected from quarters of lactating Holstein dairy cows that developed CM during lactation, including milk from both healthy and diseased quarters ( = 1,172).

Survival Rate of High-Rise Syndrome Cases Using Animal Trauma Triage Score in Cats.

Objective:  To assess the data of high-rise syndrome (HRS) cases and determine the relationship between Animal Trauma Triage Score (ATTS), height, injury profile, and survival rate of patients.

Study Design:  Retrospective study evaluating cats with HRS within a 4-year period.

Results:  A logistic regression analysis which included height, ground type, and ATTS variables was performed to predict survival rate of patients.

Investigating the effect of Zn doping and temperature on the photoluminescence behaviour of CuLaSe quantum dots.

In this study, CuLaSe and ZnCuLaSe quantum dots (QDs) with a mean size of ~4 nm were synthesized and characterized, and their temperature-dependent photoluminescence (PL) properties were studied in the temperature range from 90 to 300 K for the first time. The results show that the obtained QDs were spherical and revealed excitonic band gaps. The PL intensity for both types of materials decreased when increasing the temperature to 300 K, which was attributed to the nonradiative relaxation and thermal escape mechanisms.

Decreased lactose percentage in milk associated with quarter health disorder and hyperketolactia, a proxy for negative energy balance, in dairy cows.

Several studies have described variations in lactose content (LC) in dairy cows during udder quarter health disorder or negative energy balance (NEB). However, their joint effects on LC have never been described. This was the aim of a longitudinal observational study performed on 5 Quebec dairy farms using automatic milking systems.

Topical statins as antifungals: a review.

Cutaneous fungal infections affect millions around the world. However, severe, multi-resistant fungal infections are increasingly being reported over the past years. As a result of the high rate of resistance which urged for drug repurposing, statins were studied and found to have multiple pleiotropic effects, especially when combined with other already-existing drugs.