Publications by authors named "Minato Baba"
Article Synopsis
- - CUBN encodes a protein called cubilin, which helps reabsorb albumin in the kidneys, and its mutations are linked to a type of kidney disease known as CUBN-related proteinuria.
- - A case study of triplets shows that they experienced chronic proteinuria for 20 years due to CUBN gene variants, despite initial tests not identifying the underlying cause.
- - The identification of these CUBN mutations allows for a better understanding of their condition, potentially preventing unnecessary treatments and anxiety about kidney function.
Food allergy occurs due to IgE- and mast cell-dependent intestinal inflammation. Previously, we showed that histamine-releasing factor (HRF), a multifunctional protein secreted during allergy, interacts with a subset of IgE molecules and that the HRF dimer activates mast cells in an HRF-reactive IgE-dependent manner. In this study, we investigated whether HRF plays any role in food allergy.
View Article and Find Full Text PDFRequirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.
Proc Natl Acad Sci U S A
October 2015
The regulation of intestinal homeostasis by the immune system involves the dynamic interplay between gut commensal microbiota and resident immune cells. It is well known that a large and diverse lymphocyte antigen receptor repertoire enables the immune system to recognize and respond to a wide range of invading pathogens. There is also an emerging appreciation for a critical role the T-cell receptor (TCR) repertoire serves in the maintenance of peripheral tolerance by regulatory T cells (Tregs).
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