Publications by authors named "Minami Miura"
Cell-therapies that invoke pleiotropic mechanisms may facilitate functional recovery in stroke patients. We hypothesized that a cell therapy using microglia preconditioned by optimal oxygen-glucose deprivation (OGD) is a therapeutic strategy for ischemic stroke because optimal ischemia induces anti-inflammatory M2 microglia. We first delineated changes in angiogenesis and axonal outgrowth in the ischemic cortex using rats.
View Article and Find Full Text PDFAlthough a major function of B cells is to mediate humoral immunity by producing antigen-specific antibodies, a specific subset of B cells is important for immune suppression, which is mainly mediated by the secretion of the anti-inflammatory cytokine interleukin-10 (IL-10). However, the mechanism by which IL-10 is induced in B cells has not been fully elucidated. Here, we report that IκBNS , an inducible nuclear IκB protein, is important for Toll-like receptor (TLR)-mediated IL-10 production in B cells.
View Article and Find Full Text PDFArticle Synopsis
- Progranulin is a critical glycoprotein in the central nervous system linked to maintaining physiological functions, and mutations in its gene lead to frontotemporal degeneration.
- Although there is evidence that progranulin can protect against ischaemic brain injury, the changes in its expression and function post-injury remain poorly understood.
- In a study involving rat and mouse models, researchers found that progranulin expression increased in certain brain cells after ischaemia, with distinct changes in its glycosylation forms, indicating its potential therapeutic role and mechanisms in protecting the brain following injury.