Pharmacokinetics of solid lipid particles in healthy subjects.

Objectives: The anti-inflammatory activity of extracts (BSE) is well known. BSE comprises boswellic acids (BA) such as 3--acetyl-11-keto--boswellic acid (AKBA) and 11--boswellic acid (KBA) as major constituents. One of the limitations of BAs is their poor oral bioavailability.

Pharmacokinetics of solid lipid particles in healthy subjects.

Objectives: The anti-inflammatory activity of extracts (BSE) is well known. BSE comprises boswellic acids (BA) such as 3--acetyl-11-keto--boswellic acid (AKBA) and 11--boswellic acid (KBA) as major constituents. One of the limitations of BAs is their poor oral bioavailability.

Zebrafish: An emerging whole-organism screening tool in safety pharmacology.

During the last two decades, the development in drug discovery is slackening due to drug withdrawal from the market or reported to have postmarket safety events. The vital organ toxicities, especially cardiotoxicity, hepatotoxicity, pulmonary toxicity, and neurotoxicity are the major concerns for high drug attrition rates. The pharmaceutical industry is looking for high throughput, high content analysis based novel assays that would be fast, efficient, reproducible, and cost-effective; would address toxicity, the safety of lead molecules, and complement currently used cell-based assays in preclinical testing.

Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BSE) for osteoarthritis of knee.

Objectives The present study was planned to investigate the efficacy of SLBSP vs. standardized BSE for symptomatic knee osteoarthritis (OA) treatment. Methods It was a prospective, randomized, double-blind, double-dummy, placebo-controlled, and single-centre clinical trial for symptomatic osteoarthritis of knee.