Publications by authors named "Minako Sueoka"
Notch signaling is one of the most common drivers of carcinogenesis in many types of cancers, including hepatocellular carcinoma (HCC); however, it occasionally suppresses tumor progression. Moreover, it is virtually unknown how different sets of Notch ligands and receptors regulate the HCC development. In this study, we demonstrate that the expression of the Notch ligands, Delta-like 4 (Dll4) and Jagged-1 (Jag1), is upregulated during diethylnitrosamine-induced hepatocarcinogenesis.
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- The liver has a strong ability to regenerate after injury, but this process is often hindered in cases of advanced liver fibrosis or cirrhosis, where mature liver cells struggle to divide and replicate.
- Researchers have identified a specific population of alpha-fetoprotein (AFP)-producing cells in mice that are stimulated by Jagged1/Notch2 signaling in fibrotic livers, potentially contributing to liver regeneration.
- An increase in AFP-positive cell numbers is observed after liver injury, and this process is enhanced following liver surgery, indicating a complex interaction between activated liver cells and AFP-expressing hepatocytes mediated by Jagged1 and Notch2 pathways.